Buy PLINEST® Online

PLINEST® is a premium aesthetic and medical brand developed by Mastelli, renowned for its advanced skin and hair regeneration treatments based on PN-HPT™ (Polynucleotides Highly Purified Technology). The brand represents a scientifically-backed line of injectable biorevitalization products designed to stimulate skin regeneration, restore hydration and elasticity, and promote hair growth.
If you’re looking to buy PLINEST® online, order today from Medical Spa RX.

PLINEST® Product Line

Here’s an overview of the PLINEST® product line:

PLINEST®

PLINEST® is a 40mg/2ml injectable PN-HPT™ treatment designed to restore skin elasticity, hydration, and overall texture on the face, neck, and décolleté. It is clinically proven to reduce fine wrinkles and support bio-regeneration with visible results after 3–4 sessions.

• 40mg/2ml PN-HPT™ for face, neck, and décolleté bio-revitalization
  
• Improves hydration (+14.7%) and elasticity (+21.8%)
  
• Protocol: 3–4 sessions every 14–21 days, maintenance every 1–3 months
  
• Excellent for fine wrinkles, dull skin, and acne scars

PLINEST® EYE

PLINEST® EYE is a gentle 15mg/2ml polynucleotide formulation specifically developed for the delicate periorbital area. It improves crow’s feet, sagging eyelids, and under-eye texture while maintaining excellent tolerability.

• 15mg/2ml PN-HPT™ formulated for the periocular area
  
• Reduces crow’s feet, eyelid sagging, and dark circles
  
• Protocol: 3–4 sessions, 1–2ml per session, spaced every 14–21 days
  
• Safe for delicate skin with >90% showing clinical improvement

PLINEST® HAIR

PLINEST® HAIR is a scalp and eyebrow revitalization treatment using PN-HPT™ to stimulate hair growth and improve follicular health. It is especially effective for female hormonal alopecia, showing significant improvements in hair density and vitality.

• 15mg/2ml PN-HPT™ for hair and eyebrow bio-stimulation
  
• Increases anagen (growth) phase, decreases telogen (resting)
  
• Protocol: Phase I (4 sessions every 7–14 days), Phase II (4 sessions every 21–30 days)
  
• Over 72% of women reported improvement in hair density

PLINEST® ONE

PLINEST® ONE offers the power of polynucleotide-based skin rejuvenation in a single-session protocol, ideal for busy patients or quick refresh treatments. It delivers fast improvements in hydration, tone, and radiance with minimal downtime.

• Designed for single-session biorevitalization using PN-HPT™
  
• Suitable for patients with time constraints or for maintenance
  
• Offers fast, visible skin improvement after just one session
  
• Ideal for seasonal refresh, events, or travel-ready skin prep

PLINEST® FAST

PLINEST® FAST is a rapid-action polynucleotide solution created for accelerated aesthetic recovery and immediate skin enhancement. It’s ideal for express protocols or combination therapies needing quick, visible skin revitalization.

• A rapid-acting PN-HPT™ formula optimized for short-term recovery
  
• Enhances skin tone and texture quickly with minimal downtime
  
• Useful in express protocols or combined therapies (e.g., microneedling, peels)
  
• Provides immediate skin radiance and hydration boost

PLINEST® Protocol

PLINEST® protocols are designed with flexibility for patient-specific needs, ranging from skin rejuvenation to scar correction and hair restoration.
Key features include:

• PLINEST® (40mg/2ml): Used for face, neck, décolleté, and acne scars. Injected intradermally every 14–21 days for 3–4 sessions, followed by maintenance every 1–3 months.
  
• PLINEST® Eye (15mg/2ml): Tailored for periocular rejuvenation. Administered using micro-droplet or linear retrograde technique in 3–4 sessions spaced every 14–21 days.
  
• PLINEST® Hair (15mg/2ml): Applied to scalp and eyebrows. Phase I: 4 sessions every 7–14 days; Phase II: 4 more sessions every 21–30 days.
  
• Injection Technique: Intradermal with micro-droplets (0.1–0.2ml per point) or linear retrograde injections using 30G ½ needles.
  
• Packaging: All formulations come in 1 x 2ml pre-filled syringes.
  

Each treatment session delivers targeted regenerative action and prepares the tissue for enhanced responsiveness to adjunct therapies.

PLINEST® Indications

PLINEST® is indicated for patients experiencing skin laxity, wrinkles, dull skin, acne scars, and hormonal hair loss, offering a versatile solution for aesthetic enhancement and therapeutic interventions.
PLINEST® Core Indications:

• Fine lines and superficial wrinkles
  
• Reduced skin elasticity and hydration
  
• Acne scars and fibrotic tissue areas
  
• Aging or sagging periocular skin (PLINEST® Eye)
  
• Hair thinning, eyebrow loss, and female hormonal alopecia (PLINEST® Hair)
  

Contraindications:

• Known hypersensitivity to polynucleotides or gel components
  
• Presence of infections or inflammation at injection sites
  
• Pregnancy and breastfeeding, unless advised otherwise
  
• Active dermatological diseases in the treatment area
  

PLINEST®’s biologically active formulations make them ideal for both standalone therapy and skin priming before invasive or non-invasive cosmetic treatments.

Side Effects of PLINEST®

PLINEST® products are exceptionally well-tolerated due to their high biocompatibility and natural origin. Across all five product lines, the reported side effects are mild and transient.
Reported side effects include:

• Temporary redness, swelling, or bruising at injection sites
  
• Mild pain or discomfort during injection (especially in sensitive areas like the eyes)
  
• No reported cases of severe adverse reactions
  

PLINEST® Eye, in particular, is formulated at a lower concentration (15mg/2ml) to minimize risks in delicate zones such as the periorbital area, ensuring safety without compromising effectiveness.

How to Use PLINEST®

PLINEST® products are administered via intradermal injection by licensed medical professionals, using customized techniques based on the anatomical zone and desired outcome.
Method of Use for Each Product:

• PLINEST® (40mg/2ml): Inject 2ml per session using micro-droplet or linear retrograde methods; 3 sessions every 14–21 days, followed by maintenance every 1–3 months.
  
• PLINEST® Eye (15mg/2ml): Apply 1–2ml per session to the eye contour with spacing of 0.5–1 cm, every 14–21 days for 3–4 sessions.
  
• PLINEST® Hair (15mg/2ml): Inject 2ml into scalp or eyebrow areas with micro-droplet or linear retrograde technique; 8-session program split into two phases over 2–3 months.
  

Depth of Injection: Always intradermal
Tools: 30G ½ needles (2 per syringe)
When used consistently and correctly, PLINEST® products demonstrate significant clinical benefits in over 90% of patients, with measurable improvements in hydration, elasticity, hair density, and overall skin texture.