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REFINE + is a smooth, non-animal, stabilized, cross-linked hyaluronic acid-based filler and skin booster. 

The filler is sold with a concentration of 20 mg/ml in a solution of sodium chloride with a pH of 7. The pack contains one graduated pre-filled 1 ml syringe and two 30-gauge needles, allowing for easy administration.

If you’re looking to purchase this product, source it from a reliable supplier to keep your patients safe. 

What Is REFINE + Used For?

This formulation is used for evening out the skin, improving skin elasticity, and reducing the impression of fine lines and wrinkles. These fillers are suitable for all skin types and can be used to treat the face, neck, and hands. 

Here are some additional uses:

  • Reshaping the neckline, face, and hands 
  • Reducing the appearance of sagging skin, volume loss, fine lines, and wrinkles 
  • Improving skin texture and tone 
  • Improving the appearance of mature or photodamaged skin

As with all skin-boosting injections, the results of REFINE + treatments vary from patient to patient. On average, the effects last between six months to a year. You may need to administer subsequent maintenance or “touch-up” treatments.

REFINE + Product Range

REFINE + dermal injections are available in two product variations. Both contain hyaluronic acid as their active ingredient but have different concentrations to accommodate for immediate, safe, and non-invasive bio-revitalization effects.

The two product variations available for purchase are:

  • SOFT. This is sold in 20 mg/ml compositions with low cross-linking and is designed to correct wrinkles ranging from fine to medium. It has a complex viscosity of 50-70 Pa*s, meaning it is relatively easy to spread. It is designed to provide immediate hydration, correct minor to moderate facial skin depressions, and stimulate the production of new collagen in the skin. 
  • ULTRA SOFT. This is sold in 20 mg/ml compositions, developed to correct minor hollow areas of the face. It has a complex viscosity of 0.5-2 Pa*s, making it incredibly easy to inject and spread into the medium derma. It is designed to provide long-lasting hydration, fill out minor imperfections, and increase the production of collagen in the skin. 


Both variations are available for purchase online. Contact our experts at Medical SPA RX if you wish to buy REFINE + wholesale. 

REFINE + Side Effects

Like all hyaluronic acid fillers, REFINE + fillers have side effects. These are usually mild and disappear within the first week of treatment. They include:

  • Redness, swelling, irritation, rash, discomfort, or stinging at the injection site 
  • Bruising or hematoma formation
  • Numbness at the site of injection

In some cases, patients may experience severe side effects, especially if you use an improper administration technique. These include:

  • Early-onset nodules and lumps
  • The Tyndall Effect (bluish discoloration of the skin)
  • Malar edema
  • Abscess at the site of injection
  • Infection (symptoms such as fever, chills, leukocytosis, and fatigue may or may not be present)
  • Skin necrosis
  • Filler migration

To reduce the risk of adverse side effects, it’s recommended to order online from a licensed distributor and administer it using the proper technique. 

REFINE + Contraindications

REFINE + fillers should not be administered to individuals who: 

  • Are pregnant or lactating
  • Have cancer or autoimmune diseases 
  • Exhibit hypersensitivity to any of the formulation components
  • Have a history of severe allergic reaction or anaphylaxis to hyaluronic acid
  • Have active infection at the site of injection
  • Have glabellar necrosis
  • Experience hypersensitivity reaction to gram-positive bacterial proteins
  • Have bleeding disorders

The filler should also not be administered to individuals under 18 or over 65 years of age. 

REFINE + vs the Competition

PROFHILO is a popular competitor to this brand. It is a hyaluronic acid moisturizing treatment made with NAHYCO® technology.

Like REFINE +, PROFHILO is sold as a hyaluronic acid injectable gel that stimulates skin cell receptors to counteract skin laxity and promotes deep hydration. It is also a stabilized product, meaning the activity on dermal cells lasts longer than that of a non-stabilized gel.

PROFHILO can be administered on the hands, face, and neck—it can also treat arm, knee, and abdominal areas. This is a wider application than REFINE +, which can be administered only in the hands, neck, and facial regions. 

Where Can I Purchase REFINE +?

This brand of fillers are made by Vida SRL, an Italian manufacturer of innovative and safe medical and cosmetic devices. The product is sold in packs of one 1ml prefilled syringe with two 30G needles. 

If you’re looking for a reliable supplier to source this product from, order online from Medical SPA RX today.

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