RENEFIL

Renefil is the world’s first hybrid dermal filler combining Cross-Linked Hyaluronic Acid (HA) with Polynucleotides (PN) and Lidocaine for enhanced volumization, skin regeneration, and comfort during injection. Developed by BMI Korea, Renefil integrates the benefits of HA-based volumizing with the regenerative effects of PN, delivering a multi-functional, high-viscosity filler designed for long-lasting results and minimal side effects.
Renefil formulation—Renefil Deep Plus, Renefil Light Plus, and Renefil Ultra Plus—caters to different clinical indications, targeting everything from fine lines and lip contouring to deep folds and facial sculpting. Its patented technology and 1.875 mg/mL PN concentration ensure superior elasticity, cohesion, and tissue regeneration, with certifications across Europe, USA, Russia, China, and Korea. The HA-PN synergy also supports collagen stimulation, hydration, and anti-inflammatory benefits, making Renefil not only a volumizing filler but also a true skin health booster.

RENEFIL PRODUCT RANGE

The Renefil product line features three distinct formulations—Light Plus, Deep Plus, and Ultra Plus—each designed to address specific aesthetic concerns and anatomical depths. All products are formulated with a patented blend of Cross-Linked Hyaluronic Acid (HA), Polynucleotides (PN, 1.875mg/mL), and Lidocaine (0.3%) for effective volumizing, regenerative, and comfortable treatments. The differences lie in particle size, needle gauge, and treatment indication, allowing for a tailored approach to aesthetic rejuvenation.

Renefil Light Plus

Renefil Light Plus is the most delicate formulation in the range, specifically developed for fine lines, perioral wrinkles, and lip enhancement. With a particle size of 250μm and 30G needle compatibility, it allows for smooth, precise application in superficial dermal layers.
Key Features:

• HA concentration: 20mg/mL
• PN concentration: 1.875mg/mL
• Needle: 30G
• Particle Size: 250μm
• Injection Depth: Superficial dermis
• Target Areas: Fine wrinkles, lips, periorbital lines, forehead
• Texture: Soft, smooth flow for refined surface correction
• Duration: Up to 9–12 months

Ideal for patients seeking subtle, natural-looking rejuvenation with added hydration and collagen stimulation.

Renefil Deep Plus

Renefil Deep Plus offers a versatile solution for moderate wrinkles, nasolabial folds, and mid-face volume loss. With a medium particle size of 600μm and compatibility with 27G or 30G needles, it provides a balance between lift, moldability, and smooth injection force.
Key Features:

• HA concentration: 20mg/mL
• PN concentration: 1.875mg/mL
• Needles: 27G / 30G
• Particle Size: 600μm
• Injection Depth: Mid-to-deep dermis
• Target Areas: Nasolabial folds, cheeks, zygomatic arch, chin
• Texture: Balanced viscosity and elasticity
• Duration: Approximately 10–12 months

This formulation is ideal for restoring youthful facial contours and smoothening deeper wrinkles while promoting tissue regeneration through PN action.

Renefil Ultra Plus

Renefil Ultra Plus is engineered for deep structural support, targeting areas that require significant volume restoration and contouring, such as the temples, jawline, and chin. With a particle size of 1,000μm and 27G needle use, it provides high moldability, excellent lift capacity, and low injection force for optimal physician control.
Key Features:

• HA concentration: 20mg/mL
• PN concentration: 1.875mg/mL
• Needle: 27G
• Particle Size: 1,000μm
• Injection Depth: Deep dermis to subcutaneous layer
• Target Areas: Jawline, temples, deep nasolabial folds, chin
• Texture: High cohesiveness and volumizing power
• Duration: Proven longevity up to 14 months in clinical settings

Backed by a double-blind, randomized clinical trial comparing it to Restylane Perlane, Renefil Ultra Plus showed equal or better performance in wrinkle correction and patient satisfaction with a longer duration of action.

RENEFIL Protocol

Renefil’s treatment protocol is designed for flexible application across various facial zones. Each formulation features uniform particle sizes, tailored viscosity, and high moldability for specific depth and anatomical indications.
Key product specifications and injection areas:

• Renefil Light Plus
  • Particle Size: 250 μm
  • Needle: 30G
  • Indicated Areas: Fine wrinkles, perioral lines, lips
  • Injection depth: Superficial to mid dermis
• Renefil Deep Plus
  • Particle Size: 600 μm
  • Needle: 27G or 30G
  • Indicated Areas: Nasolabial folds, chin, nose, zygomatic
  • Injection depth: Mid to deep dermis
• Renefil Ultra Plus
  • Particle Size: 1,000 μm
  • Needle: 27G
  • Indicated Areas: Deep nasolabial folds, temples, facial contouring
  • Injection depth: Deep dermis to subcutaneous

Common Characteristics Across Products:

• HA Concentration: 20 mg/mL
• PN Concentration: 1.875 mg/mL
• Lidocaine: 0.3% for pain relief
• Supplied as 1 pre-filled syringe with 2 needles

RENEFIL Indications

Renefil products are designed for a wide range of aesthetic rejuvenation and facial volumizing treatments. They offer a solution for patients looking to address volume loss, fine lines, deep wrinkles, and skin dullness with added regenerative benefits.
Primary Indications:

• Renefil Light Plus: Superficial wrinkles, crow’s feet, lip contouring
• Renefil Deep Plus: Nasolabial folds, marionette lines, mid-face volume loss
• Renefil Ultra Plus: Facial contouring, temples, chin, deep folds

Mechanism of Action:

• HA provides physical volume and hydration
• PN (Polynucleotides) stimulate fibroblast growth, collagen synthesis, and tissue repair
• Lidocaine ensures injection comfort

Contraindications:

• Known allergies to HA, PN, or lidocaine
• Active skin infections or inflammatory conditions
• Pregnancy and breastfeeding without physician supervision

Side Effects of Renefil

Renefil is developed using 4L™ Technology (Low BDDE, Low Temperature, Long Reaction, Long Dialysis), ensuring low residual chemicals and high biocompatibility. This significantly reduces the likelihood of adverse reactions.
Reported Side Effects:

• Mild redness, bruising, or swelling at injection site
• Temporary tenderness or firmness in treated area
• Rare risk of nodules, hypersensitivity, or vascular events

Safety Features:

• HA sourced from EU-approved suppliers (EDQM)
• Minimal BDDE usage with extended dialysis for purification
• Clinical trials confirm non-inferiority to top competitors like Restylane Perlane over a 6-month period

How to Use RENEFIL

Renefil should be administered by trained medical professionals using techniques appropriate to the target area and product viscosity. The injection depth and needle size differ across product lines to match the intended anatomical plane.
Recommended Use:

• Injection Method: Linear threading, serial puncture, or fanning
• Syringe Contents: 1.0 mL per syringe
• Injection Depths:
  • Light Plus: Superficial dermis
  • Deep Plus: Mid-to-deep dermis
  • Ultra Plus: Deep dermis to subcutaneous layer

Shelf Life & Storage:

• Store in a cool, dry place
• Use before expiration marked on the syringe

Longevity:

• Clinical data suggests Renefil Ultra Plus maintains shape and volume for up to 12–14 months, outperforming competitors in degradation resistance.