JUVÉDERM®
Buy JUVÉDERM® online from Medical Spa Rx and stock your clinic with the world’s most widely used hyaluronic acid filler brand. Developed by AbbVie, the JUVÉDERM® collection of fillers includes more than ten products built on VYCROSS® and HYLACROSS™ technologies, covering lips, cheeks, jawline, folds, and skin quality. Licensed practitioners can order JUVÉDERM® online at wholesale prices, with temperature-controlled shipping, LOT-verified stock, and fast license approval. Browse the range below and place your order today.
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About JUVÉDERM® — AbbVie’s HA Filler Collection
JUVÉDERM® is the world’s most widely used brand of hyaluronic acid fillers, originally developed by Allergan and now part of AbbVie following the 2020 acquisition. The gels are produced at the Allergan manufacturing site in Pringy, France, with US-market products made to FDA manufacturing standards.
JUVÉDERM® injectable gels are sterile HA dermal fillers placed in the dermis or deeper tissue to restore volume, refine facial contours, and soften lines. The formulation is cross-linked sodium hyaluronate in phosphate-buffered saline, with lidocaine added to the XC versions. HA attracts and binds water molecules at the treatment site, which adds volume and hydration, and the cross-linking makes the gel durable and resistant to enzymatic degradation.
The JUVÉDERM® collection of dermal fillers spans two cross-linking technologies: VYCROSS® (VOLUMA®, VOLLURE™/VOLIFT™, VOLBELLA®, VOLUX™, VOLITE®) and HYLACROSS™ (the ULTRA range). Depending on the product, JUVÉDERM® dermal fillers treat midface and cheek volume loss, jawline and chin definition, lip augmentation, nasolabial folds, marionette lines, undereye hollows, and overall skin quality.
VYCROSS® vs HYLACROSS™ — Technology Overview
VYCROSS® technology combines high molecular weight (HMW) and low molecular weight (LMW) HA chains in a single cross-linked network. Including the shorter chains improves cross-linking efficiency, which lets VYCROSS® gels deliver lift and longevity at a lower HA concentration [5]. The result is a highly cohesive, smooth gel with excellent tissue integration, easy extrusion, and longer duration. VYCROSS® is used in VOLUMA®, VOLLURE™/VOLIFT™, VOLBELLA®, VOLUX™, and VOLITE®. Its practical advantages are superior longevity, a smoother feel, and lower water affinity, which helps limit post-treatment swelling.
HYLACROSS™ technology is the original JUVÉDERM® platform. It cross-links HA chains of uniform molecular weight at high concentration. Unlike sized HA products, HYLACROSS™ gels are not broken up through sieves, so they remain smooth and cohesive [4]. HYLACROSS™ is used in ULTRA XC, ULTRA PLUS XC, ULTRA 3, and ULTRA 4. These JUVÉDERM® hyaluronic acid fillers have a long, well-validated clinical track record, though duration is slightly shorter than the newer VYCROSS® generation.
In practice, VYCROSS® is the choice for longevity and structural work, while HYLACROSS™ remains a proven, cost-effective option for lips and folds.
Buy JUVÉDERM® Products — Full Range with Clinical Detail
JUVÉDERM® VOLUMA® XC
[Image — alt: JUVEDERM VOLUMA cheek filler]
Indication: Deep injection in the cheek area to correct age-related midface volume loss in adults over 21. In the US, JUVÉDERM® VOLUMA® XC is also approved for augmentation of the chin region and for augmentation of the temple to correct moderate to severe temple hollowing in adults [3].
Why preferred: VOLUMA® is the longest-lasting JUVÉDERM® volumizer, with results of up to 24 months in the cheeks per FDA approval data. Its firm G’ (elastic modulus) provides genuine structural lifting capacity, making it the gold-standard cheek product in the range.
Administration: Deep supraperiosteal or deep subcutaneous injection in the cheek and midface using a needle or cannula. Contains lidocaine (XC) for patient comfort.
JUVÉDERM® VOLIFT™ (JUVÉDERM® VOLLURE™ XC in the US)
Indication: Moderate to severe facial wrinkles and folds, including nasolabial folds (smile lines) and marionette lines. VOLLURE™ XC is the US brand name and VOLIFT™ is the EU/international name for the same VYCROSS® gel.
Why preferred: Designed for mid-face lines and folds that need natural softening without the stiffness of deeper volumizers. It offers a balanced G’ and high cohesivity, with FDA data showing improvement up to 18 months in a majority of subjects. When choosing a JUVÉDERM® product for marionette lines, VOLLURE™/VOLIFT™ is the clinical recommendation within the range.
Administration: Mid-dermis to deep dermis injection with a needle or cannula along the nasolabial fold or marionette line. Contains lidocaine.
JUVÉDERM® VOLBELLA® XC
Indication: Lip augmentation and correction of perioral lines in adults over 21. In the US, VOLBELLA® XC is also approved for improving the appearance of undereye hollows (infraorbital hollows) in adults over 21, with Allergan’s product training required before injecting this area [2].
Why preferred: The softest, lowest-G’ VYCROSS® gel, tuned specifically for delicate tissue. It delivers the subtlest result among JUVÉDERM® lip fillers and is the go-to for natural enhancement and fine vertical “smoker’s lines,” with an FDA-approved duration of up to 12 months in the lips.
Administration: Submucosal or intradermal injection into the lip body and vermilion border. Cannula technique is commonly used to minimize bruising. As with all XC products, VOLBELLA® XC contains lidocaine.
JUVÉDERM® ULTRA XC / JUVÉDERM® ULTRA PLUS XC
[Image — alt: JUVEDERM ULTRA XC lip filler]
Indications: ULTRA XC is FDA-approved for lip augmentation in adults over 21 and for moderate to severe facial wrinkles and folds. ULTRA PLUS XC is FDA-approved for deeper, more severe facial wrinkles and folds [3]. Both use HYLACROSS™ technology.
Why preferred: These are the most widely used JUVÉDERM® products globally, the legacy workhorses of the ULTRA line. ULTRA XC is the everyday choice when a clinic wants to balance lip augmentation cost against proven performance, and ULTRA PLUS XC handles the deeper folds. Both contain lidocaine.
Administration: Intradermal to subcutaneous injection. ULTRA XC is used for lip work and the perioral area, with typical lip duration of 9–12 months. ULTRA PLUS XC is placed in nasolabial folds and deeper wrinkles.
JUVÉDERM® VOLUX® XC
[Image — alt: JUVEDERM VOLUX jawline filler]
Indication: Jawline definition and chin augmentation. In the US, JUVÉDERM® VOLUX™ XC is approved for deep injection to improve moderate to severe loss of jawline definition in adults over 21 [1][3]. It is the newest and highest-G’ product in the VYCROSS® portfolio.
Why preferred: The only JUVÉDERM® product purpose-built for the lower face, and the first HA filler to receive FDA approval for jawline definition [1]. It provides a structural scaffold that softer gels cannot, and per FDA labelling and AbbVie’s approval announcement, jawline definition results last up to 12 months with optimal treatment [1].
Administration: Deep supraperiosteal or deep subcutaneous injection along the jawline, mandibular angle, and chin using a blunt cannula or needle. Contains lidocaine (XC).
JUVÉDERM® VOLITE® (SKINVIVE™ by JUVÉDERM® in the US)
Indication: Skin quality improvement, including hydration, texture, and fine lines. SKINVIVE™ is the US brand name for the product sold internationally as VOLITE®. It is a microinjection skin booster rather than a volumizing filler, and in the US it is FDA-approved for improving cheek skin smoothness.
Why preferred: The only JUVÉDERM® product that is grouped with other skinboosters, competing directly with Restylane® SKINBOOSTERS™, Teosyal® REDENSITY I, and Profhilo®.
Administration: Serial puncture or retrograde linear technique with multiple superficial intradermal microinjections across the face; neck, décolletage, and hands are treated off-label. Results last around 6 months, with maintenance sessions.
JUVÉDERM® HYDRATE®
Indication: Skin hydration and quality improvement, historically available in EU/international markets and not FDA-approved. It uses non-cross-linked or lightly cross-linked HA for skin biorevitalization, a similar indication to VOLITE® with a different formulation profile.
Why preferred: An established EU-market skin booster for practitioners who prefer a single-brand facial protocol. Availability varies by market and may be limited, so verify current distribution with AbbVie or the local distributor before quoting patients.
Administration: Microinjection technique across the face, neck, and décolletage.
JUVÉDERM® VOLITE® LIPS (Off-Label Lip Hydration)
Indication: VOLITE® is indicated for filling fine lines and improving skin hydration and elasticity in the face, neck, décolletage, and hands. It has no dedicated lip indication, but practitioners may use off-label VOLITE® microinjections for lip hydration and a subtle “lip gloss” effect. For volume-based lip enhancement, JUVÉDERM® VOLBELLA® or ULTRA XC remain the on-label choices.
Why preferred: Best for patients who want improved lip skin quality — dryness, fine vertical lines, and overall texture — without any volumizing effect.
Administration: Superficial intradermal microdroplet injection via serial puncture or cannula. Cannula technique is preferred in the lip to minimize bruising and reduce intravascular risk. This is an off-label use for trained, licensed injectors.
JUVÉDERM® ULTRA 3 / ULTRA 4
Indication: EU/international HYLACROSS™ range. ULTRA 3 treats moderate lines and adds lip volume (comparable to ULTRA XC, though without lidocaine in some markets). ULTRA 4 treats deeper folds and volume loss (comparable to ULTRA PLUS XC).
Why preferred: Cost-effective HYLACROSS™ options in EU markets where the ULTRA XC versions are unavailable or where budget is a deciding factor.
Administration: Intradermal to deep subcutaneous injection depending on viscosity. ULTRA 3 is used for lips and moderate folds. ULTRA 4 is placed in deeper nasolabial folds and severe facial wrinkles.
JUVÉDERM® VOLUMA® (non-XC / EU version)
Indication: Cheek augmentation and midface volume restoration, using the same VYCROSS® formulation as VOLUMA® XC but without lidocaine.
Why preferred: Chosen in clinical settings where practitioners apply topical anesthesia or nerve blocks and prefer a lidocaine-free product. It remains a common request in EU markets alongside the XC version.
Administration: Identical to VOLUMA® XC. Deep injection in the cheek and midface.
JUVÉDERM® VOLBELLA® (non-XC / EU version)
Indication: Lip augmentation and perioral lines, using the same VYCROSS® gel as VOLBELLA® XC without lidocaine.
Why preferred: For EU practitioners who manage anesthesia separately, including cases where a separate anesthetic approach is preferred for perioral corrections.
Administration: Submucosal or intradermal injection into the lips and perioral area.
JUVÉDERM® Compared to Other HA Fillers
JUVÉDERM® competes with several established hyaluronic acid filler brands. Here is how JUVÉDERM® stacks up against its main HA competitors.
Note: On the JUVÉDERM® vs BOTOX®comparison, BOTOX® is a neuromodulator that relaxes muscles to reduce dynamic wrinkles, while JUVÉDERM® is an HA filler that restores volume, so the two are usually combined rather than compared.
JUVÉDERM® vs Restylane®
Restylane® (Galderma) is JUVÉDERM®’s most direct global competitor. Restylane® uses NASHA® (a firmer, particulate gel) and XpresHAn Technology™ (designed for dynamic expression), while JUVÉDERM® relies on cohesive VYCROSS® and HYLACROSS™ gels. The difference matters clinically. VYCROSS® products are often cited for a smoother feel and easier injection, whereas NASHA® products are frequently preferred for structural lifting, such as Restylane® LYFT in the cheeks. For lips, ULTRA XC and VOLBELLA® compete with Restylane® KYSSE, all FDA-approved. KYSSE emphasizes expression flexibility, while VOLBELLA® offers a softer, more cohesive result. For the undereye, Restylane® EYELIGHT™ is Galderma’s dedicated product, and JUVÉDERM® VOLBELLA® XC holds its own US approval for undereye hollows [2]. In skin boosters, Restylane® SKINBOOSTERS™ and VOLITE®/SKINVIVE™ address comparable indications. On longevity, VOLUMA® (up to 24 months) outlasts most Restylane® cheek products. Both brands are fully reversible with hyaluronidase.
JUVÉDERM® vs BELOTERO®
BELOTERO® (Merz) uses Cohesive Polydensified Matrix (CPM) technology, producing a gel that integrates evenly through tissue. Its main clinical advantage is superficial fine-line treatment. CPM gels integrate into the superficial dermis with low Tyndall effect risk, giving BELOTERO® an edge for very superficial periorbital lines and skin depressions. JUVÉDERM®’s VYCROSS® range, by contrast, is broader and more indication-comprehensive, covering cheeks, jawline, lips, folds, and skin boosters, and BELOTERO® has no jawline product comparable to VOLUX™. For deep volumizing and structural work, JUVÉDERM® is the stronger option. BELOTERO® remains a niche choice for superficial and periorbital work. Both are CE-marked and hold FDA approvals in the US.
JUVÉDERM® vs TEOSYAL®
TEOSYAL® (Teoxane, Switzerland) builds its flagship range on RHA® (Resilient Hyaluronic Acid) technology, engineered for areas of facial movement. RHA® products are designed to stretch with facial expressions and recover, which is a validated advantage in dynamic zones such as the perioral area and nasolabial folds. JUVÉDERM® has no equivalent movement-tuned engineering in that specific sense. For static volume and longevity in the cheeks, JUVÉDERM® VOLUMA® (up to 24 months) outperforms comparable TEOSYAL® products. For lips, TEOSYAL® PURESENSE KISS (CE-marked) competes with ULTRA XC and VOLBELLA®, which carry FDA lip approvals. Under the eyes, TEOSYAL® PURESENSE REDENSITY II is a dedicated tear trough product with strong European data, while JUVÉDERM®’s counterpart in the US is VOLBELLA® XC [2].
JUVÉDERM® vs REVANESSE®
REVANESSE® (Prollenium, Canada) positions itself on tolerability, particularly low post-treatment swelling. REVANESSE® LIPS+ is its most discussed lip product, often cited for minimal perioral swelling. ULTRA XC has a longer clinical track record for lips, and JUVÉDERM®’s range depth is far greater. VOLUMA®, VOLUX™, VOLITE®/SKINVIVE™, VOLLURE™, and VOLBELLA® together cover many more indications than REVANESSE®’s current portfolio. REVANESSE® suits practitioners looking for a single cost-effective lip or fold product, while JUVÉDERM® is better for those who want a comprehensive single-brand full-face protocol.
JUVÉDERM® vs STYLAGE®
STYLAGE® (Laboratoires VIVACY, France) uses IPN-Like cross-linking with mannitol, an antioxidant intended to reduce post-injection edema and extend HA longevity by neutralizing free radicals. This mannitol component is STYLAGE®’s main differentiator and is not present in JUVÉDERM®. STYLAGE® offers a wide EU range from fine lines to deep volumizing and lips, but VYCROSS® products have stronger longevity data (VOLUMA® at up to 24 months), and STYLAGE® has no US FDA approval. For EU practitioners, the decision usually comes down to pricing and STYLAGE®’s edema-reduction argument versus JUVÉDERM®’s brand recognition and longevity data.
JUVÉDERM® vs SAYPHA®
SAYPHA® (Croma Pharma, Austria) is a CE-marked HA range that includes SAYPHA® FILLER, SAYPHA® RICH, and SAYPHA® VOLUME, covering fine lines, volume restoration, and deep implantation, with lidocaine-containing versions available. SAYPHA® is not FDA-approved and is positioned as a cost-competitive European alternative. JUVÉDERM® leads on brand recognition, depth of clinical evidence, and breadth of FDA approvals. EU clinics may choose SAYPHA® on price, while JUVÉDERM® is preferred wherever a strong evidence base and global patient familiarity matter. Both are reversible with hyaluronidase.
Duration, Safety, and Side Effects
Duration in the JUVÉDERM® range varies by product and treatment area. VOLUMA® lasts up to 24 months in the cheeks. VOLLURE™/VOLIFT™ improvement extends up to 18 months in a majority of subjects. VOLBELLA® provides up to 12 months in the lips. ULTRA XC typically holds for 9–12 months in the lips. VOLUX™ delivers jawline definition results for up to 12 months with optimal treatment [1]. SKINVIVE™/VOLITE® lasts around 6 months with maintenance sessions. Results generally become visible from about two weeks post-treatment, once any initial swelling has resolved.
JUVÉDERM® fillers are CE-marked, and the XC range is FDA-approved in the US, each backed by clinical trial data. Common side effects are generally mild and short-lived, including redness, swelling, pain, tenderness, and bruising at the treatment site, with temporary redness that usually settles within a few days. Rare events include pigmentation disorders and vascular occlusion, the latter being technique-dependent. The safety profile is well established when injections are performed by trained practitioners with sound anatomical knowledge.
Where to Buy JUVÉDERM® Wholesale Online
Medical Spa Rx is a trusted wholesale platform for licensed aesthetic practitioners looking to buy JUVÉDERM® wholesale and purchase JUVÉDERM® online with confidence. Our platform features a price beat program, free shipping on orders over $1,000, a 14-day delivery guarantee (often sooner within the USA), temperature-controlled shipping for HA filler products, and a fast 24-hour license verification process, all of which make it straightforward to buy JUVÉDERM® online.
Order JUVÉDERM® wholesale with no minimum order requirements. Every order includes LOT-verified authentic products, volume-based wholesale savings, a dedicated account manager, and fully tracked international fulfillment.
Clinics that buy JUVÉDERM® products through our platform can browse the product grid above for current pricing, or contact the team for a bulk quote.
Frequently Asked Questions
What kind of filler is JUVÉDERM®?
JUVÉDERM® consists of cross-linked hyaluronic acid gels formulated for different facial aesthetic applications, from fine correction to structural support.
How do VYCROSS® and HYLACROSS™ differ?
VYCROSS® combines different molecular weights of HA in its gel network, while HYLACROSS™ is the earlier technology used primarily in the ULTRA family.
Which JUVÉDERM® product is designed for cheek volume?
VOLUMA® XC is used for deep cheek and midface correction and has clinical data supporting results lasting up to 24 months.
Does JUVÉDERM® have a product for jawline definition?
Yes. VOLUX™ XC is formulated for structural treatment of the lower face and is FDA-approved in the US for improving moderate to severe loss of jawline definition.
Is VOLITE® the same type of treatment as a traditional filler?
VOLITE®, sold as SKINVIVE™ in the US, is used for skin-quality improvement through superficial microinjections rather than conventional facial volumizing.
How long can results from JUVÉDERM® remain visible?
Duration depends on the formulation and treatment area, ranging from around six months for skin-quality treatments to as long as 24 months for VOLUMA® in the cheeks.
Can a JUVÉDERM® treatment be reversed?
HA gel can be broken down with hyaluronidase when reversal is clinically necessary.
What does the XC designation on JUVÉDERM® mean?
XC identifies formulations that contain lidocaine to help improve comfort during injection.
Can licensed clinics order JUVÉDERM® wholesale from Medical Spa Rx?
Yes. Medical Spa Rx offers JUVÉDERM® ordering for licensed practitioners, including volume-based savings, LOT-verified products, tracked shipping, and bulk-order support.
Disclaimer: The page and all of its displayed contents are for medical professionals, designed to inform only, and not as a replacement for medical advice.
Citations
[1] AbbVie. “FDA Approves JUVÉDERM® VOLUX™ XC for Improvement of Jawline Definition.” AbbVie News Center, 3 Aug. 2022, news.abbvie.com/2022-08-03-FDA-Approves-JUVEDERM-R-VOLUX-TM-XC-for-Improvement-of-Jawline-Definition.
[2] AbbVie. “FDA Approves JUVÉDERM® VOLBELLA® XC for Undereye Hollows.” AbbVie News Center, 8 Feb. 2022, news.abbvie.com/2022-02-08-FDA-Approves-JUVEDERM-R-VOLBELLA-R-XC-For-Undereye-Hollows.
[3] AbbVie. “JUVÉDERM® Jawline Filler Treatment.” JUVÉDERM®, www.juvederm.com/treatment/jawline-filler.
[4] Mansouri, Yasaman, and Gary Goldenberg. “Update on hyaluronic acid fillers for facial rejuvenation.” Cutis vol. 96,2 (2015): 85-8.
[5] Micheels, Patrick et al. “Visual, Ultrasonographic, and Microscopic Study on Hyaluronic Acid-Based Gel.” Journal of drugs in dermatology : JDD vol. 15,9 (2016): 1092-8.
Written and reviewed by the Medical Spa Rx Editorial Team
All clinical and product claims on this page have been checked against peer-reviewed research, manufacturer data, and regulatory sources in accordance with our Editorial Policy .