What Are the Purporte Benefits of Cagrilintide (5mg)?
Cagrilintide (5mg), also known as NN0174-0833, AM833, and EX-A10092, is a long-acting amylin analogue that has been examined in preclinical and translational research models for its interactions with amylin and calcitonin receptors. These receptor systems are involved in physiological pathways governing gastric motility, appetite signaling, and energy regulation, making them of interest to metabolic research.
In non-clinical settings, cagrilintide has been studied for its effects on satiety signaling, gastric emptying kinetics, and modulation of metabolic pathways. These investigations examine how prolonged activation of the amylin receptor may influence feeding behavior and postprandial metabolic responses under controlled experimental conditions. No therapeutic benefit or clinical efficacy is implied.
What Is the Chemical Makeup of Cagrilintide (5mg)?
Cagrilintide (5mg) is a synthetic analogue of human amylin, consisting of 37 amino acids and engineered to enhance molecular stability and prolong systemic exposure. The peptide backbone is derived from the native human amylin sequence, with strategically placed amino acid modifications and lipid conjugation to reduce aggregation and enzymatic degradation.
Rather than isolated point substitutions, cagrilintide’s design incorporates sequence optimization and N-terminal lipidation, distinguishing it from native amylin and earlier analogues.
Other Specifications
- Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
- Molecular Weight: 4409 g/mol
- CAS Number: 1415456-99-3
- Purity: ≥98% (verified by HPLC and mass spectrometry)
- Peptide Sequence: XKCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP
The molecule includes lipidation via a γ-glutamic acid spacer linked to a C20 dicarboxylic fatty acid, a modification that significantly extends peptide stability and circulating half-life in experimental models when compared with native human amylin.
What Does Scientific Research Say About Cagrilintide (5mg)?
Cagrilintide (5mg) remains an investigational research compound. Scientific literature primarily focuses on:
- Receptor binding and signaling profiles at amylin and calcitonin receptors
- Pharmacokinetic behavior resulting from lipid conjugation
- Effects on gastric motility and appetite-related signaling in non-clinical models
- Tolerability and mechanistic outcomes observed under controlled experimental conditions
No claims regarding the treatment, prevention, or management of disease have been established. Human clinical efficacy and long-term safety outcomes remain outside the scope of research-grade material descriptions.
What Are the Storage Conditions for Cagrilintide (5mg)?
Lyophilized Cagrilintide should be stored at –20°C or below, protected from light and moisture, to preserve structural integrity and analytical consistency. When stored under these conditions, the lyophilized peptide is generally stable for 1–2 years.
Once reconstituted for research use, solutions should be stored at 2–8°C and may be used for up to 4 weeks, provided sterile handling conditions are maintained. Reconstituted solutions should not be frozen, as repeated freeze–thaw cycles may lead to peptide aggregation, precipitation, and degradation.
For storage beyond the recommended post-reconstitution period, the peptide should remain in lyophilized form at –20°C or lower. Proper storage and handling are essential to ensure consistency and reliability in experimental applications.
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This product is supplied strictly for laboratory research use only and is not approved for human or veterinary administration. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes.
Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines. By purchasing or using this material, the buyer confirms that they are a qualified researcher and that the product will be used exclusively in controlled research settings compliant with all applicable regulations.
Sources
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00565
https://www.nejm.org/doi/full/10.1056/NEJMoa2502081
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01163-7/abstract