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CJC-1295 – With DAC is a synthetic growth hormone-releasing hormone analog with albumin-binding properties and an extended half-life of 6–8 days, studied in neuroendocrine research. Research suggests that it may provide sustained growth hormone and IGF-1 elevation through prolonged GHS-R receptor engagement, enabling investigation of continuous versus pulsatile GH signaling dynamics, receptor regulation mechanisms, and metabolic effects of sustained hormone elevation in experimental systems.

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General info
Brand

NOVERA COMPOUNDS

Strength

5mg

CAS

863288-34-0

Chemical Formula

C₁₅₂H₂₅₂N₄₄O₄₂

Molecular weight

3647.17 g/mol

Peptide Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-LysLys(Maleimidopropionyl)-NH2

Synonyms

CJC1295, CJC-1295 with DAC

Storage

Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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Why Novera Compounds?

Advanced synthesis techniques ensure high structural fidelity and ≥99% purity.

Independent laboratories confirm identity, purity, and batch consistency.

Designed for reproducible laboratory and analytical applications.

Products meet Research Use Only (RUO) standards and relevant laboratory regulations.

Certificates of Analysis and quality verification reports provided for every lot.

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CJC-1295 – With DAC (5mg) About This Product

The CJC peptide is a synthetic 29-amino-acid analog of growth hormone–releasing hormone (GHRH) that incorporates a Drug Affinity Complex (DAC). Laboratories that buy CJC peptide or order CJC peptide materials reference this formulation for controlled laboratory research examining long-acting GHRH analog behavior and growth-hormone–axis signaling under experimental conditions.

The DAC modification enables reversible binding to serum albumin, resulting in prolonged peptide persistence in circulation compared with native GHRH and short-acting analogs. In research models, this extended exposure enables investigation of sustained growth hormone signaling dynamics over longer observation windows.

CJC-1295 with DAC has been evaluated in early-phase clinical research programs. Although clinical development was discontinued, published data remain relevant to laboratory studies of endocrine signaling behavior and long-term regulatory mechanisms.

Product Specifications

  • Molecular weight: ~3,350–3,650 g/mol (including DAC and acetate)
  • Molecular formula: C₁₅₉H₂₅₈N₄₆O₄₅
  • CAS number: 446262-90-4
  • Purity:95%, verified by HPLC
  • Form: Lyophilized powder

CJC-1295 – With DAC (5mg) Key Features and Benefits

  • Chemical identity: 29-amino-acid GHRH analog with DAC modification
  • Purity: Commonly produced at ≥95%, verified by HPLC
  • Long-acting format: Evaluated in research models requiring extended peptide exposure
  • Albumin-binding property: Studied for its effect on peptide persistence in circulation
  • Research focus: Used in laboratory investigations of sustained growth-hormone–axis signaling
  • Format: Supplied as a lyophilized powder suitable for controlled laboratory handling

For laboratory research use only.

CJC-1295 – With DAC (5mg) Mechanism & Research Applications

CJC-1295 with DAC has been examined in laboratory research as a long-acting GHRH analog used to study endogenous growth-hormone release mechanisms under sustained exposure conditions. In experimental systems, the peptide interacts with pituitary cell models, while the DAC component prolongs systemic availability through albumin binding.

This extended activity profile enables researchers to investigate regulatory responses associated with continuous growth hormone signaling rather than pulsatile secretion.

Research applications include:

  • Growth-hormone–axis signaling studies under prolonged stimulation
  • Endocrine regulation research models examining downstream signaling markers
  • Metabolic regulation investigations focused on experimental hormone dynamics
  • Long-duration exposure studies assessing cumulative signaling behavior

All applications described reflect controlled laboratory research contexts and do not imply clinical or therapeutic use.

CJC-1295 – With DAC (5mg) Dosing & Observed Effects in Research

Research protocols involving CJC-1295 with DAC vary by study design, species, and experimental objective. Published laboratory and early clinical research describes experimental dosing frameworks designed to evaluate prolonged peptide activity and sustained signaling behavior.

Reported laboratory observations include time-dependent changes in growth-hormone–related biomarkers, IGF-1-associated signaling markers, and other assay-specific molecular readouts. These findings are derived exclusively from controlled research environments and do not establish safety, efficacy, or therapeutic relevance.

Researchers who order CJC peptide materials are expected to establish dose-response parameters appropriate to their specific experimental models, as outcomes vary by protocol, species, and analytical endpoints.

CJC-1295 – With DAC (5mg) Storage, Safety & References

  • Store lyophilized vials at ≤ –20 °C for long-term stability
  • Short-term storage at 2–8 °C is acceptable when necessary
  • Keep vials sealed, dry, and protected from light
  • Allow vials to equilibrate to room temperature before opening
  • Reconstitute only with bacteriostatic water using sterile technique
  • Store reconstituted solutions at 2–8 °C and use within 2–3 weeks
  • Avoid repeated freeze–thaw cycles

Handle materials in accordance with institutional laboratory biosafety procedures. Review the Certificate of Analysis (CoA) and Safety Data Sheet (SDS) prior to use.

References

https://pubmed.ncbi.nlm.nih.gov/16352683

https://pubmed.ncbi.nlm.nih.gov/17018654

https://pubmed.ncbi.nlm.nih.gov/19386527

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.