FOXO4 — About This Product
FOXO4 peptide is a synthetic version of the FOXO4 protein, which plays a role in managing cellular stress and longevity. It is made up of 46 amino acids in the D-form (the mirror image of natural amino acids) with a molecular weight of approximately 5.4 kDa (5,358 Da). This peptide is supplied as a lyophilized powder in a 10 mg vial, with a purity of ≥98%.
The FOXO4 peptide has been studied for its potential to regulate cellular senescence, DNA repair, and oxidative stress. Researchers use this peptide in laboratory settings to explore its role in aging, stress responses, and cell regeneration.
FOXO4 — Key Features and Benefits
- High Purity: ≥98% purity, verified for reliable results.
- Convenient Format: Lyophilized powder, provided in a 10 mg vial for easy reconstitution.
- Research Focus: Investigated for its role in aging, oxidative stress, and DNA repair.
- Laboratory-Ready: Suitable for in vitro and ex-vivo studies, compatible with various research protocols.
FOXO4 — Mechanism & Research Applications
Experts use FOXO4 for research to study how it influences cellular processes related to aging, stress adaptation, and DNA repair. Researchers focus on its potential role in cell regeneration and senescence (when damaged cells stop dividing), which could help understand aging and tissue health.
It has also been studied for its impact on oxidative stress and metabolic functions, particularly in how cells respond to damage. However, the findings are currently based on preclinical research, and human clinical trials are not available.
FOXO4 — Dosing & Observed Effects in Research
No clinical trials have been conducted for the FOXO4 peptide, so safe and effective human dosing has not been established. In preclinical research, doses ranged from 5–10 mg/kg body weight administered intravenously over a period of 5 days. In cell-based studies, typical concentrations used were 5–25 µM, but these do not translate to human dosing.
In animal models, FOXO4 can influence cellular behavior and stress-response pathways, though these findings are from research settings and do not imply therapeutic outcomes.
FOXO4 — Storage, Safety & References
- Storage: Store FOXO4 peptide lyophilized at –20°C, away from light and moisture.
- Reconstitution: After reconstitution with sterile, pyrogen-free solvent, store at 2–8°C and use within 5–7 days.
- Handling: Use aseptic techniques and wear PPE (gloves, lab coat) during preparation and experimentation.
- Safety: Avoid freeze-thaw cycles to preserve peptide integrity. Dispose of unused material according to local regulations.
References
https://pmc.ncbi.nlm.nih.gov/articles/PMC5556182
https://pmc.ncbi.nlm.nih.gov/articles/PMC8116695
https://pmc.ncbi.nlm.nih.gov/articles/PMC7053614
https://www.nature.com/articles/s41467-019-13931-7
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17333
Compliance Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use.