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Name: GHRP-2 (10mg)
Brand: NOVERA COMPOUNDS
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GHRP-2 is a synthetic growth hormone–releasing peptide studied for its effects on endocrine signaling. Research suggests that it may stimulate growth hormone secretion and metabolic activity, primarily through activation of ghrelin receptors involved in pituitary hormone release.

General info

Brand	NOVERA COMPOUNDS
Strength	10mg
CAS	158861-67-7
Chemical Formula	C₄₅H₅₅N₉O₆
Molecular weight	817.97 g/mol
Peptide Sequence	H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Synonyms	GHRP2, Pralmorelin, Growth Hormon Releasing Peptide-2
Storage	Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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GHRP-2 (10mg) About This Product

GHRP-2 (10mg) is a synthetic growth hormone–releasing peptide developed for endocrine, metabolic, and neurobiological research. It is a hexapeptide composed of six amino acids, with a molecular weight of approximately 817 Da, and incorporates multiple D-amino acid residues that enhance conformational stability and resistance to enzymatic degradation in experimental environments.

The GHRP-2 peptide has been examined in laboratory and preclinical research settings for its role as a synthetic agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), also known as the ghrelin receptor. Activation of GHS-R1a initiates Gq/phospholipase C (PLC) signaling and calcium-dependent intracellular cascades that regulate growth hormone release, metabolic sensing, and energy-balance signaling under controlled experimental conditions.

This product is supplied as a sterile, lyophilized powder with reported purity ≥98%, packaged in a sealed, research-grade vial. It is intended exclusively for non-clinical laboratory research, including receptor pharmacology, signal-transduction studies, and hormone-regulated biological process investigations.

GHRP-2 (10mg) Key Features and Benefits

Growth Hormone Secretagogue Receptor (GHS-R1a) Agonist: Selective binding to the ghrelin receptor enables detailed pharmacological studies of receptor activation and downstream signaling
D-Amino Acid Composition: Incorporation of D-amino acids enhances peptide stability and resistance to enzymatic degradation
Short-Chain Synthetic Peptide: Hexapeptide structure suitable for receptor-specific endocrine research
Research-Grade Purity: ≥98% purity appropriate for analytical and experimental workflows
Lyophilized Formulation: Supports long-term stability and controlled reconstitution
Sealed Research Vials: Ensures traceability and contamination control

Researchers who buy GHRP-2 peptide typically select this 10mg vial format for controlled receptor and signal-transduction studies.

GHRP-2 (10mg) Mechanism & Research Applications

GHRP-2 functions as a synthetic agonist of GHS-R1a, a G protein-coupled receptor (GPCR) expressed in the pituitary gland, hypothalamus, and multiple peripheral tissues. Upon receptor engagement, GHRP-2 activates Gq/PLC signaling, leading to inositol triphosphate (IP₃) generation, intracellular calcium mobilization, and protein kinase activation. These signaling events modulate growth hormone secretion, metabolic energy sensing, appetite regulation, and gene-expression programs associated with cellular growth and stress response.

In research settings, GHRP-2 is used to interrogate GHS-R1a activation kinetics, downstream signal-transduction cascades, and tissue-specific receptor expression and function.

Research Applications by Domain

1. Receptor Pharmacology

Evaluation of GHS-R1a activation, ligand specificity, and receptor desensitization
Structure–activity relationship (SAR) analyses of growth hormone secretagogues

2. Muscle Biology

Investigation of protein synthesis and degradation pathways
Examination of the ubiquitin–proteasome system, including modulation of atrogin-1 and MuRF1 expression

3. Energy Balance & Feeding Regulation

Studies of hypothalamic and peripheral nutrient-sensing networks
Assessment of food-intake patterns, appetite-related behavioral outcomes, and metabolic signaling

4. Cardiac Cell Stress & Bioenergetics

Cardiomyocyte culture and myocardial injury models
Evaluation of apoptosis markers, oxidative-stress pathways, and mitochondrial function

5. Immunology & Thymic Function

Investigation of thymic signaling pathways and T-cell maturation processes
Assessment of thymic output and immune-cell diversity in aging or stress models

6. Neurobiology

Studies of sleep–wake regulation and sleep-stage distribution
Examination of nociceptive processing and opioid-receptor crosstalk in neural systems

Comparative research frequently includes side-by-side evaluation with other growth hormone–related peptides to assess receptor selectivity, signaling bias, and downstream biological effects.

GHRP-2 (10mg) Dosing & Observed Effects in Research

Published research involving GHRP-2 commonly reports use at microgram-level concentrations, with dosing adjusted according to experimental model, route of administration, and study design. Research investigations span diverse model systems, including cell-culture platforms, tissue explants, rodent and murine models, and large-animal preclinical studies.

Observed outcomes commonly include measurable endpoints such as:

Growth hormone elevation
Alterations in food-intake patterns and appetite-related behaviors
Changes in muscle protein synthesis and ubiquitin-ligase expression (atrogin-1 and MuRF1 modulation)
Shifts in cardiomyocyte apoptosis and oxidative-stress markers
Thymic output and T-cell maturation parameters
Modifications in sleep-stage distribution and nociceptive processing
Altered activation of receptor-mediated signaling cascades

All findings derive exclusively from preclinical laboratory and animal research models and remain model-specific.

GHRP-2 (10mg) Storage, Safety & References

Store GHRP-2 (10mg) as a lyophilized powder protected from light and moisture.

Short-term storage: 2–8 °C (days to weeks)
Long-term storage: −20 °C or lower (−80 °C preferred)

Avoid repeated freeze–thaw cycles. After reconstitution, storage conditions depend on solvent choice and protocol duration. Handle using standard laboratory safety practices, including appropriate personal protective equipment, sterile technique, and compliant disposal procedures. Laboratories that order GHRP-2 peptide must ensure storage, handling, and disposal follow institutional biosafety and chemical hygiene requirements.