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Name: GHRP-6 (5mg)
Brand: NOVERA COMPOUNDS
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GHRP-6 is a synthetic peptide studied for its role in growth hormone release and appetite-related signaling. Research suggests that it may influence endocrine and metabolic regulation, primarily through stimulation of ghrelin receptors involved in hormone secretion and feeding behavior.

General info

Brand	NOVERA COMPOUNDS
Strength	5mg
CAS	87616-84-0
Chemical Formula	C₄₆H₅₆N₁₂O₆
Molecular weight	873.03 g/mol
Peptide Sequence	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Synonyms	GHRP6, Growth Hormone Releasing Peptide-6
Storage	Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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Why Novera Compounds?

Precision-Synthesized Peptides

Advanced synthesis techniques ensure high structural fidelity and ≥99% purity.

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Research-Grade Reliability:

Designed for reproducible laboratory and analytical applications.

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GHRP-6 (5mg) About This Product

GHRP-6 (5mg) is a synthetic growth hormone–releasing hexapeptide used in endocrine, neuroendocrine, and metabolic research. The GHRP-6 peptide has a molecular weight of ~840 Da and incorporates L- and D-amino acid residues, which can affect proteolytic susceptibility and receptor-interaction profiles in experimental settings.

GHRP-6 has been examined as a synthetic agonist of the growth hormone secretagogue receptor-1a (GHS-R1a), also called the ghrelin receptor. Receptor activation initiates Gq/phospholipase C (PLC) signaling and calcium-dependent intracellular cascades relevant to growth hormone release and related neuroendocrine signaling under controlled research conditions.

This product is supplied as a sterile, lyophilized powder with ≥98% purity in a sealed research vial. Laboratories that buy GHRP-6 peptide commonly use the 5 mg format for non-clinical study designs.

GHRP-6 (5mg) Key Features and Benefits

GHS-R1a (Ghrelin Receptor) Agonist: Supports receptor pharmacology and signaling assays
D-Amino Acid Composition: Associated with improved experimental stability
Low Molecular Weight (~840 Da): Practical for controlled handling
Lyophilized Powder: Supports stability and flexible preparation
Purity ≥98%: Suitable for research and analytical workflows
Sealed, Labeled Vial: Supports traceability and documentation

GHRP-6 (5mg) Mechanism & Research Applications

GHRP-6 acts at GHS-R1a, a GPCR expressed in the pituitary, hypothalamus, central nervous system, and select peripheral tissues. Activation triggers Gq/PLC-dependent signaling, leading to inositol triphosphate (IP₃) generation, intracellular calcium mobilization, and kinase activation. These cascades are used to study growth hormone secretion dynamics, metabolic sensing, and gene-expression programs linked to cellular stress, inflammatory signaling, and apoptosis-associated pathways.

In research contexts, GHRP-6 is used to probe GHS-R1a activation kinetics, tissue-specific receptor expression, and downstream signal-transduction networks.

Primary Research Domains

Receptor Pharmacology: Ligand-response profiling, second-messenger readouts, structure–activity work
Neuroscience: Learning/memory endpoints, synaptic plasticity, dopaminergic involvement
Ischemia & Cellular Stress: Apoptosis markers and neuroinflammatory signaling
Extracellular Matrix & Tissue Remodeling: Matrix signatures, migration, wound-model profiling
Cardiac Stress Models: Oxidative injury and necrosis-related endpoints
Motivation & Reward Circuitry: Region-specific behavioral outputs

Preclinical Research Summary

Neural Plasticity & Memory: Extinction learning, amygdala-associated LTD, memory encoding
Ischemic Brain Injury: Apoptosis-associated markers and neuroinflammation readouts
Dopaminergic Mapping: GHS-R expression in substantia nigra linked to motor phenotypes
ECM Remodeling: Collagen deposition and proteome-level repair signatures
Myocardial Injury/Oxidative Stress: Oxidative injury indices and necrosis markers
Motivation & Reward-Seeking: CNS region–dependent effects on motivated behavior

GHRP-6 (5mg) Dosing & Observed Effects in Research

Published studies report microgram-to-milligram use depending on model and design, including cell-based assays, tissue explants, rodent studies, and large-animal preclinical models.

Observed endpoints reported in research settings include:

Growth hormone elevation
Learning/memory-related behavioral changes
Apoptosis and necrosis signaling markers
Inflammatory cytokine pathway modulation
Oxidative-stress and antioxidant-response markers
Extracellular-matrix expression and collagen deposition
Reward-seeking and motivated-behavior outputs
Dopaminergic neuron response modulation

All findings remain preclinical and model-specific.

GHRP-6 (5mg) Storage, Safety & References

Store lyophilized material protected from light and moisture:

Short-term: 2–8°C (days to weeks)
Long-term: −20°C or lower (−80°C preferred). Avoid repeated freeze–thaw cycles.

Reconstitute using sterile laboratory-grade diluent under aseptic technique. Handle with standard PPE and dispose of per institutional requirements. Laboratories that order GHRP-6 peptide are responsible for compliance.