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Name: IGF-1 DES (1mg)
Brand: NOVERA COMPOUNDS
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IGF-1 DES is a truncated analog of insulin-like growth factor-1 designed for growth factor signaling research with enhanced tissue-specific receptor activity. Research suggests it may help support localized tissue repair and growth processes by modulating IGF-1 receptor signaling with reduced binding protein interference. It appears to work through preferential activation of tissue-specific IGF-1 pathways involved in cellular proliferation and differentiation.

General info

Brand	NOVERA COMPOUNDS
Strength	1mg
CAS	112603-35-7
Chemical Formula	C₃₁₉H₅₀₁N₉₁O₉₆S₇
Molecular weight	7371.48 g/mol
Synonyms	IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3
Storage	Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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IGF-1 DES (1mg) About This Product

The IGF-1 DES peptide (also referred to as des(1–3)-IGF-1 or IGF-1 (4–70)) is a synthetic, truncated analogue of insulin-like growth factor-1 composed of 67 amino acids, with a molecular weight of approximately 7,365.4 Da. Laboratories that buy IGF-1 DES peptide or order IGF-1 DES peptide materials reference this compound for controlled laboratory research examining IGF signaling behavior and binding-protein interactions in experimental systems.

IGF-1 DES is derived from the naturally occurring cleavage of full-length IGF-1, in which the first three N-terminal amino acids (Gly-Pro-Glu) are removed. This structural modification results in reduced affinity for insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3, a property that has been examined in comparative cell-based research models.

The product is supplied as a lyophilized powder in 1 mg glass vials, commonly produced at >95% purity as verified by analytical testing, and intended exclusively for laboratory research use.

IGF-1 DES (1mg) Key Features and Benefits

Chemical identity: Truncated IGF-1 analogue (des(1–3)-IGF-1)
Amino acid length: 67 amino acids
Molecular weight: ~7,365.4 Da
Purity: Commonly reported at >95%, verified by analytical methods
Format: Supplied as a lyophilized powder in sterile vials
Binding characteristics: Reduced interaction with IGF binding proteins compared with full-length IGF-1
Research scope: Studied in laboratory models examining IGF signaling and cellular response patterns

For laboratory research use only.

IGF-1 DES (1mg) Mechanism & Research Applications

IGF-1 DES has been examined in laboratory research as a bioactive IGF-1 variant evaluated for its interaction with the IGF-1 receptor under controlled experimental conditions. Due to its truncated N-terminus, the peptide demonstrates altered binding behavior relative to full-length IGF-1, which is used in research to study IGF signaling in the presence of reduced IGFBP modulation.

Research applications include:

IGF-receptor signaling studies in cell culture systems
Comparative binding investigations examining IGF-1 variants and IGFBP interactions
Neuronal and metabolic cell models used for experimental signaling analysis
Tissue-specific signaling research evaluating short-term cellular response markers

All applications described reflect controlled laboratory research contexts and do not imply clinical or therapeutic use.

IGF-1 DES (1mg) Dosing & Observed Effects in Research

Published research involving IGF-1 DES primarily reports experimental concentration ranges rather than standardized dosing protocols. In in vitro studies, the peptide is commonly evaluated at nanogram-per-milliliter concentrations, with working ranges adjusted according to cell type and assay design.

Reported laboratory observations include concentration-dependent changes in cellular signaling markers and other assay-specific molecular readouts. These findings are derived exclusively from controlled laboratory and preclinical research environments and do not establish safety, efficacy, or clinical relevance.

Researchers who order IGF-1 DES peptide materials are expected to establish experimental parameters appropriate to their specific model systems.

IGF-1 DES (1mg) Storage, Safety & References

Store lyophilized vials at –18 °C to –20 °C, protected from light and moisture
Maintain vials in a desiccated environment when not in use
Reconstitute only with sterile water, PBS, DMEM, or dilute acetic acid using aseptic technique
Store reconstituted solutions at 2–8 °C for short-term use
For longer storage, aliquot and freeze at –20 °C or –80 °C
Avoid repeated freeze–thaw cycles