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Name: IGF-1 LR3 (1mg)
Brand: NOVERA COMPOUNDS
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IGF-1 LR3 is a synthetic insulin-like growth factor analog designed for research with enhanced receptor binding and extended half-life. Research suggests it may support cell growth and protein synthesis by prolonging IGF-1 receptor activation. Moreover, it may work by reducing interactions with binding proteins while maintaining IGF-1 signaling pathways.

General info

Brand	NOVERA COMPOUNDS
Strength	1mg
CAS	946870-92-4
Chemical Formula	C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular weight	9117.60 g/mol
Peptide Sequence	MFPAMPLSSL–FVNGPRTLCG–AYGGSCASFR–RGFYFNKPTG–YGSSTKKAYG–NNYRRHPLLK–PPIKSAQG
Synonyms	Long R3-IGF-1, M9L22Y19H9, 143045-27-6, Long-(arg3)insulin-like growth factor-i, IGF-I analog
Storage	Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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Why Novera Compounds?

Precision-Synthesized Peptides

Advanced synthesis techniques ensure high structural fidelity and ≥99% purity.

Third-Party Verified Quality:

Independent laboratories confirm identity, purity, and batch consistency.

Research-Grade Reliability:

Designed for reproducible laboratory and analytical applications.

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Products meet Research Use Only (RUO) standards and relevant laboratory regulations.

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Certificates of Analysis and quality verification reports provided for every lot.

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IGF-1 LR3 (1mg) About This Product

The IGF-1 peptide, specifically IGF-1 LR3 (Long Arg³ insulin-like growth factor-1), is a synthetic analogue of native human insulin-like growth factor-1 developed for controlled laboratory research. Laboratories that buy IGF-1 peptide or order IGF-1 peptide materials reference IGF-1 LR3 for experimental studies examining IGF signaling behavior and binding-protein interactions in research systems.

IGF-1 LR3 consists of 83 amino acids and has a molecular weight of approximately 9,117.5 g/mol. Compared with endogenous IGF-1, which contains 70 amino acids, this analogue includes a 13-amino-acid N-terminal extension and a single amino acid substitution at position 3. These structural modifications reduce interaction with insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3, a property examined in comparative laboratory studies.

The product is supplied as a lyophilized powder in 1 mg glass vials, commonly produced at ≥95–99% purity as verified by analytical testing, and intended exclusively for laboratory research use.

IGF-1 LR3 (1mg) Key Features and Benefits

Chemical identity: Modified IGF-1 analogue (IGF-1 LR3)
Amino acid length: 83 amino acids
Molecular weight: ~9,117.5 g/mol
Purity: Commonly reported at ≥95–99%, verified by analytical methods
Format: Supplied as a lyophilized powder in sterile glass vials
Binding characteristics: Reduced interaction with IGF binding proteins compared with native IGF-1
Research scope: Studied in laboratory models examining IGF receptor signaling and cellular response patterns

For laboratory research use only.

IGF-1 LR3 (1mg) Mechanism & Research Applications

IGF-1 LR3 has been examined in laboratory research as a modified IGF-1 variant evaluated for its interaction with the IGF-1 receptor under controlled experimental conditions. Due to reduced IGFBP binding, the peptide is used in research systems to explore IGF signaling behavior with altered binding-protein modulation.

Research applications include:

IGF receptor signaling studies in cell culture models
Comparative binding investigations assessing IGF-1 variants and IGFBP interactions
Muscle, adipocyte, and developmental cell systems used for experimental signaling analysis
Preclinical growth-factor research models evaluating short-term cellular response markers

All applications described reflect controlled laboratory research contexts and do not imply clinical or therapeutic use.

IGF-1 LR3 (1mg) Dosing & Observed Effects in Research

Reported research use of IGF-1 LR3 varies across experimental designs, model systems, and analytical endpoints. In in vitro studies, the peptide is typically evaluated at nanogram-per-milliliter concentrations, with working ranges adjusted based on cell type and assay requirements.

Preclinical animal research has explored experimental infusion and exposure protocols to assess IGF-related signaling markers, cellular response patterns, and other assay-specific molecular readouts. These observations are derived exclusively from controlled laboratory and animal research environments and do not establish safety, efficacy, or clinical relevance.

Researchers who order IGF-1 peptide materials are expected to define experimental parameters appropriate to their specific model systems.

IGF-1 LR3 (1mg) Storage, Safety & References

Store lyophilized vials at –18 °C to –20 °C, protected from light and moisture
Maintain vials in a desiccated environment when not in use
Reconstitute only with sterile water, PBS, or appropriate laboratory media using aseptic technique
Store reconstituted solutions at 2–8 °C for short-term use
For extended storage, aliquot and freeze at –20 °C or –80 °C
Avoid repeated freeze–thaw cycles