Product Description
LATISSE® Product Overview
LATISSE® is a prescription treatment developed for hypotrichosis of the eyelashes, a condition characterized by inadequate lash growth. LATISSE® works as a prostaglandin analog, promoting longer, thicker, and darker eyelashes. Administered via a nightly application on the upper eyelid margin, it is generally well-tolerated, providing visible results within 8-16 weeks.
Key Features:
- Active Ingredient: Bimatoprost 0.3 mg/mL
- Application: Once nightly on the upper eyelid margin
- Primary Action: Increases lash growth in terms of length, thickness, and darkness
- Pack Size: 5ml in a 5ml bottle with 140 applicators
LATISSE® Indications for Use
LATISSE® is indicated for eyelash hypotrichosis treatment, specifically enhancing the length, thickness, and pigmentation of lashes. Patients often observe noticeable improvements by the end of a 16-week treatment cycle.
Primary Indications:
- Eyelash Growth: Increases the length, density, and darkness of eyelashes for those experiencing thin or sparse lash growth.
LATISSE® Dosage Information
LATISSE® is intended for nightly application using sterile applicators included in the package. Application on the lower lid is not advised due to potential unintended hair growth on nearby areas.
Application Protocol:
- Dosage: Apply one drop of LATISSE® on the sterile applicator, applying it along the upper eyelid margin at the base of the lashes.
- Frequency: Once nightly; additional applications do not enhance results.
- Precautions: Remove makeup and contact lenses before application. Blot any excess product outside the lash line with a tissue.
Expected Outcomes:
- Onset of Results: Visible growth improvement typically begins after 8 weeks, with full effects around 16 weeks.
- Post-Treatment Changes: If treatment is discontinued, lashes gradually return to their baseline appearance over several weeks to months.
LATISSE® Side Effects and Precautions
LATISSE® has a favorable safety profile but may lead to mild side effects in some patients. Notable precautions are advised for those using intraocular pressure-lowering agents, as LATISSE® may reduce their effectiveness.
Common Side Effects:
- Eye Itching or Redness: Reported in about 4% of patients.
- Skin Pigmentation: Darkening of the upper eyelid skin, which may be reversible upon discontinuation.
- Eye Dryness or Irritation: Occasional reports of ocular discomfort or dryness.
Warnings and Precautions:
- Intraocular Pressure (IOP) Concerns: Patients using intraocular pressure-lowering agents should consult with their physician before use, as LATISSE® may interfere with desired IOP reduction.
- Iris Pigmentation: Increased pigmentation of the iris (brown coloring) may occur, which is typically irreversible.
- Periorbital Hair Growth: LATISSE® should be applied only to the upper eyelid margin, as excess application may result in hair growth in unintended areas.
- Handling Precautions: Use a new applicator for each eyelid to avoid contamination, which can lead to infections.
LATISSE® Clinical Studies or Real-World Outcomes
Clinical trials for LATISSE® demonstrate significant efficacy, with patients observing longer, thicker, and darker lashes by week 16.
Study Findings:
- Eyelash Prominence: 78% of LATISSE® users reported a one-grade increase in overall lash prominence by week 16, compared to 18% of the control group.
- Measurement Outcomes: On average, eyelash length increased by 25%, thickness by 106%, and darkness by 18%.
- Patient Satisfaction: High satisfaction due to improvements in lash appearance, with minimal side effects in the majority of patients.
Clinical Observations:
- Efficacy in Adolescents: LATISSE® has also shown safe use in teenagers with hypotrichosis, providing similar efficacy to adults.
- Gradual Effect Reversal: After the 16-week application cycle, effects diminish over time if treatment is stopped, reverting to the baseline lash appearance.
LATISSE® Composition and Active Ingredients
LATISSE® contains bimatoprost 0.3 mg/mL as its active ingredient, supported by other compounds that stabilize the solution for safe, effective use on delicate eye tissues.
Key Ingredients:
- Bimatoprost: A prostaglandin analog that extends the anagen (growth) phase of eyelash hair cycles.
- Benzalkonium Chloride: A preservative; contact lenses should be removed before application and reinserted 15 minutes later to prevent lens discoloration.
LATISSE® Drug Interactions
While LATISSE® has minimal systemic absorption, precautions are necessary for patients using medications that may interact with prostaglandin analogs.
Important Considerations:
- Concurrent Use with Prostaglandin Analogs: Patients using other prostaglandin analogs for IOP management should consult their physician, as LATISSE® may reduce the effectiveness of these medications.
- Intraocular Anti-Inflammatories: LATISSE® should be used cautiously in patients with active intraocular inflammation due to potential exacerbation.
