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MT-1 is a synthetic analog of alpha-melanocyte–stimulating hormone (α-MSH), developed for melanocortin system research. Research suggests that it may stimulate melanin production and skin pigmentation through activation of melanocortin-1 receptors (MC1R), supporting studies of melanogenesis, pigmentation signaling, and cellular responses involved in photoprotection.

$51.00

General info
Brand

NOVERA COMPOUNDS

Strength

10mg

CAS

75921-69-6

Peptide Sequence

Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val

Molecular weight

1646.874 g/mol

Synonyms

MT-1

Storage

Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.

Shelf life

24 months from the manufacturing date.

Disclaimer: Sold as a research-grade lyophilized peptide in dry powder form. Requires reconstitution under controlled laboratory conditions. Reconstitution agents are not included.

For Research Use Only (RUO): Not for human or animal use, consumption, injection, or application. Not for diagnostic, therapeutic, or clinical purposes.

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Why Novera Compounds?

Advanced synthesis techniques ensure high structural fidelity and ≥99% purity.

Independent laboratories confirm identity, purity, and batch consistency.

Designed for reproducible laboratory and analytical applications.

Products meet Research Use Only (RUO) standards and relevant laboratory regulations.

Certificates of Analysis and quality verification reports provided for every lot.

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What Are The Purported Benefits Of MT-1?

MT-1 peptide, also known as the melanotan 1 peptide, is a synthetic analog of the natural hormone α-melanocyte-stimulating hormone (α-MSH). It plays a key role in stimulating melanin production, supporting sunless tanning, and offering photoprotection. By targeting the MC1 receptor, MT-1 enhances eumelanin synthesis and protects the skin against UV-induced damage.

Clinically, MT-1 (branded as Scenesse) is FDA-approved for the treatment of Erythropoietic Protoporphyria (EPP), a disorder that causes extreme sun sensitivity. Compared with MT-2, MT-1 has a more favorable side-effect profile, making it an ideal choice for researchers seeking targeted skin pigmentation without significant adverse reactions. Researchers who buy MT-1 for research purposes often investigate its potential for both cosmetic tanning and skin protection.

What Is the Chemical Makeup of MT-1?

MT-1 is a 13–amino acid synthetic peptide derived from the endogenous hormone α-melanocyte-stimulating hormone (α-MSH). It incorporates specific amino acid substitutions and terminal modifications designed to enhance molecular stability and receptor selectivity in experimental settings.

Amino Acid Sequence

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Key Structural Modifications

  • Norleucine (Nle) substitution to reduce oxidative degradation
  • D-Phenylalanine (D-Phe) to improve receptor interaction
  • N-terminal acetylation and C-terminal amidation to enhance stability
  • Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉
  • Molecular Weight: 1646.874 g/mol
  • CAS Number: 75921-69-6
  • Sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

What Does Scientific Research Examine About MT-1?

MT-1 has been investigated in both preclinical and clinical studies for its interactions with melanocortin receptors, particularly MC1R. Experimental findings indicate that MT-1 is a potent melanocortin receptor agonist, commonly used to study melanocyte signaling, pigment-related pathways, and receptor-mediated cellular responses.

Pharmacokinetic evaluations in humans report an approximate half-life of ~1 hour following subcutaneous administration, reflecting greater stability than native α-MSH while remaining suitable for controlled research observation.

Regulatory Context: Afamelanotide (marketed as Scenesse) is FDA-approved for the treatment of erythropoietic protoporphyria (EPP). Note: The MT-1 material described here is supplied strictly for laboratory research use only and is not intended for human administration.

What Are the Storage Conditions for MT-1?

Proper storage is essential to preserve peptide integrity and reproducibility in research applications.

  • Lyophilized Form: Store at –20°C or lower in a dry, light-protected environment. Under these conditions, MT-1 is typically stable for 2+ years, per supplier Certificate of Analysis (CoA).
  • Reconstituted Solution: After reconstitution with bacteriostatic water, store at 2–8°C and use within 7–14 days under sterile conditions. Avoid agitation and repeated handling to minimize degradation.

Following these guidelines supports consistent peptide performance across experimental studies.

Are you looking to buy MT-1 online?

If you’re looking to order MT-1 online at wholesale prices, contact Medical Spa RX for guidance on how to do so.

This product is supplied strictly for laboratory research use only and is not approved for human or veterinary administration. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines. By purchasing or using this material, the buyer confirms that they are a qualified researcher and that the product will be used exclusively in controlled research settings compliant with all applicable regulations.

Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10418475

https://pubmed.ncbi.nlm.nih.gov/9113347

https://go.drugbank.com/drugs/DB04931

https://ec.europa.eu/health/documents/community-register/2014/20141222130241/anx_130241_en.pdf