What Are The Purported Benefits Of MT-2 (Melanotan 2)?
Melanotan 2 (MT-2) peptide is widely recognized for its potent biological effects, particularly in stimulating melanin production, making it a valuable tool in research settings. As the melanotan-2 tanning peptide, MT-2 promotes deep pigmentation with minimal UV exposure.
In addition to its tanning effects, MT-2 has been studied for its potential to enhance libido and suppress appetite. This has led to interest in its use for research on weight loss and sexual function.
Initially investigated for its role in erectile dysfunction, MT-2 continues to attract researchers interested in exploring its effects on pigmentation, metabolic signaling, and neuroendocrine pathways. Researchers often buy MT-2 to study these complex biological functions.
What Is the Chemical Makeup of MT-2 (Melanotan II)?
MT-2 is a synthetic cyclic heptapeptide derived from the endogenous hormone α-melanocyte-stimulating hormone (α-MSH). It is structurally engineered to improve conformational stability and receptor interaction relative to the native peptide. The defining feature of MT-2 is its cyclic lactam structure, which constrains the molecule into a biologically active conformation and enhances resistance to enzymatic degradation.
Amino Acid Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
The cyclization is formed through a lactam bridge between aspartic acid and lysine, a modification central to its broad melanocortin receptor affinity.
- Molecular Formula: C₅₀H₆₉N₁₅O₉
- Molecular Weight: 1024.198 g/mol
- Peptide Class: Cyclic melanocortin analogue
- CAS Number: 121062-08-6
- Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
This well-defined structure allows MT-2 to be used in controlled laboratory studies examining melanocortin receptor signaling.
What Does Scientific Research Examine About MT-2 (Melanotan II)?
MT-2 has been examined in preclinical and early clinical studies as a nonselective melanocortin receptor agonist. Experimental data show interaction with multiple melanocortin receptors, including MC1, MC3, MC4, and MC5, making it a useful tool for studying receptor-mediated pathways related to pigmentation, central signaling, and neuroendocrine regulation.
Reported Effects in Early Clinical Studies
Historical clinical investigations and case reports have described a range of physiological responses associated with melanocortin receptor activation, including gastrointestinal, autonomic, and central nervous system effects. These observations are context-specific and reflect early exploratory studies, not approved therapeutic use.
MT-2 is not approved by major regulatory agencies, including the U.S. FDA, and is restricted to laboratory research use only. It is not intended for human administration.
What Are the Storage Conditions for MT-2 (Melanotan II)?
Appropriate storage is essential to maintain peptide integrity and experimental reliability.
- Lyophilized Form: Store at –20°C or lower in a dry, light-protected environment. Under these conditions, MT-2 is typically stable for 2+ years, per supplier Certificate of Analysis (CoA).
- Reconstituted Solution: After reconstitution with bacteriostatic water, store at 2–8°C and use within 1–4 weeks, per supplier CoA, under sterile handling conditions. Avoid agitation and repeated freeze–thaw cycles, as these may compromise peptide stability.
Following these guidelines supports consistent performance in research applications.
Are you looking to buy MT-2 (Melanotan 2) online?
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This product is supplied strictly for laboratory research use only and is not approved for human or veterinary administration. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines. By purchasing or using this material, the buyer confirms that they are a qualified researcher and that the product will be used exclusively in controlled research settings compliant with all applicable regulations.
Sources
https://pmc.ncbi.nlm.nih.gov/articles/PMC6388891
https://pubmed.ncbi.nlm.nih.gov/8637402
https://pubmed.ncbi.nlm.nih.gov/9679884
https://bpspubs.onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0704437