PROFHILO® STRUCTURA is a next-generation injectable designed to restore superficial fat compartments in the face, counteracting age-related volume loss and flattening of facial contours. Unlike traditional fillers, it works biologically to regenerate and reposition fat tissue, producing natural-looking lift without projection or stiffness.
- Hybrid Cooperative Complex (HCC) of HA: 45 mg H-HA + 45 mg L-HA per 2 mL
- NAHYCO® patented technology: thermal bonding without chemical cross-linkers
- Targets superficial facial fat, not dermis
- Addresses midface hollows, sagging, loss of definition
- Produces natural lifting effect without artificial volume
- 95% of patients saw improvement after the first treatment
- Effects last at least 3 months
PROFHILO® STRUCTURA – Indications
PROFHILO® STRUCTURA is indicated for patients showing signs of facial aging related to fat loss. It’s ideal for those with “sinkers” (hollowing) or “saggers” (drooping tissue) due to ageing or rapid weight loss (e.g. post-Ozempic® use).
- Treatment of:
- Midface volume loss
- Flattening of facial angles
- Superficial fat atrophy
- Suitable for:
- Adults 30+ experiencing early or moderate signs of aging
- Patients after dramatic weight loss
- Those wanting subtle, natural rejuvenation
- Applied to preauricular area (upper cheek)
- Not a dermal filler or skin booster
PROFHILO® STRUCTURA – Ingredients
PROFHILO® STRUCTURA contains 90 mg of ultrapure hyaluronic acid per 2 mL syringe, formed from a hybrid of high and low molecular weight HA, produced without chemical cross-linking.
- Total HA content: 90 mg / 2 mL
- High molecular weight HA (H-HA): 45 mg (1100–1400 kDa)
- Low molecular weight HA (L-HA): 45 mg (80–100 kDa)
- NAHYCO® technology ensures:
- Stabilization through thermal processing
- No BDDE or other chemical agents
- High biocompatibility with adipose tissue
PROFHILO® STRUCTURA – How To Use
The treatment protocol consists of 2 sessions, spaced one month apart, using a cannula technique to target the superficial fat layers in the midface. The procedure is minimally invasive with little to no downtime.
- Injection depth: Subcutaneous (fat layer)
- Injection sites: Preauricular zone
- Tools provided:
- 2 TSK cannulas (22Gx50mm and 25Gx38mm)
- 2 pilot needles (21Gx25mm and 23Gx19mm)
- Administered via “Sinker” protocol for patients with hollowing
- Minimal downtime; patients resume activities the same day
PROFHILO® STRUCTURA – Side Effects
PROFHILO® STRUCTURA demonstrates high tolerability with no serious adverse events reported in clinical studies. Minor, temporary side effects may occur as with any injectable.
- Mild side effects may include:
- Redness, swelling, tenderness at injection site
- Temporary bruising
- No cross-linked chemicals = low risk of hypersensitivity
- Cannula injections reduce risk of vascular events by 77.1%
PROFHILO® STRUCTURA – Clinical Studies
Clinical trials confirm that PROFHILO® STRUCTURA restores volume, improves contour, and increases tissue thickness. It is supported by both physician and patient assessments.
- +23% increase in midface tissue thickness after 3 months (p<0.05)
- 95% of patients reported visible improvement after 1st treatment
- Sustained benefit at 3 months in zygomatic and jawline areas
- No adverse reactions reported in clinical trials
- Effective in both saggers and sinkers ageing profiles
PROFHILO® STRUCTURA – Manufacturer Information
PROFHILO® STRUCTURA is developed and manufactured by IBSA Derma, a Swiss-Italian pharmaceutical company specializing in ultrapure hyaluronic acid injectables. The company controls the entire production cycle, from HA fermentation to final packaging.
- Manufacturer: IBSA Farmaceutici Italia S.r.l.
- Brand: IBSA Derma
- HQ: Lodi, Italy
- Available in 80+ countries
- Uses Streptococcus equi (non-haemolytic) for HA production
- Patented process ensures molecular weights between 40 kDa and 3 MDa
PROFHILO® STRUCTURA – FAQ
Is PROFHILO® STRUCTURA a filler?
No, it is a regenerative treatment targeting superficial fat, not a dermal filler. It offers biological repositioning rather than mechanical volume.
What makes it different from regular PROFHILO®?
Regular PROFHILO® works in the dermis for skin texture and hydration. STRUCTURA acts in the fat layer for lifting and contouring.
How long does it last?
Clinical results are visible up to 3 months, often longer with maintenance.
Can it be used after weight loss?
Yes, it’s indicated for restoring facial fat after drug-induced or lifestyle-related weight loss.
Is the treatment safe?
Yes. It uses ultrapure HA with no chemical cross-linking and has a low risk of complications due to cannula use.
Can it be combined with other treatments?
Yes, but it should be spaced properly. Avoid mixing with cross-linked fillers in the same session.
