PT-141 – About This Product
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide derived from alpha-melanocyte-stimulating hormone (α-MSH)designed for laboratory research into melanocortin receptor function and neural pathways. As a structural derivative of Melanotan II, this peptide selectively targets melanocortin receptors in the central nervous system. Its molecular formula is C50H68N14O10, with a molecular weight of approximately 1025.2 Da.
This PT 141 peptide is typically supplied as a lyophilized powder in a sealed vial, commonly presented as a PT 141 10 mg vial for ease of reconstitution and dosing in laboratory settings. This peptide has been studied for its role in central melanocortin receptor modulation, sexual motivation, and neuroendocrine signaling pathways.
PT-141 – Key Features and Benefits
- High Purity: ≥98% purity, verified through HPLC, ensuring reliable experimental results
- Convenient 10 mg Vial: Each vial contains a precise amount of peptide for easy handling and controlled dosing
- Selective Receptor Activity: Investigated for its role in activating melanocortin receptors (MC1R, MC3R, MC4R, and MC5R) and its influence on behavioral and neuroendocrine pathways
- Research Focus: Studied for potential applications in understanding melanocortin-mediated neural signaling, motivation systems, and behavioral responses
- Easy to Reconstitute: The peptide is water-soluble, allowing for straightforward reconstitution with sterile, bacteriostatic water
- Stable Storage: Maintains integrity when stored at –20°C and in sealed vials, providing long-term stability
- Strict Quality Control: Manufactured under stringent testing protocols, ensuring minimal contamination and consistent quality
- For Laboratory Research Use Only: Researcehrs should buy PT 141 product only for use in vitro and in vivo research applications exclusively
PT-141 – Mechanism & Research Applications
Researchers use PT-141 for research as a melanocortin receptor agonist, particularly for its selective interaction with MC3R, MC4R, and other melanocortin receptor subtypes expressed in the hypothalamus and other brain regions. These receptors are involved in regulating behavioral responses, neuroendocrine control, reward processing, and neural pathways related to motivation and arousal.
Furthermore, PT-141 has been explored in research models for its effects on central neural circuitsinvolved in sexual motivation, behavioral responses, andneuroendocrine regulation. Its activation of melanocortin receptors makes it a valuable research tool for understanding how these signaling pathways influence behavior, appetite regulation, and related physiological systems in experimental settings.
PT-141 – Dosing & Observed Effects in Research
In preclinical studies, PT-141 sexual health peptide is typically tested at doses ranging from 0.5 mg to 2 mg per kilogramof body weight, with most animal studies using single-dose administration via subcutaneous or intravenous routes. Researchers commonly reconstitute a PT 141 10 mg vial to create the desired concentrations for in vitro or in vivo models.
Key research findings include:
- Melanocortin pathway activation: Observable at dose-dependent levels, influencing hypothalamic neuronal activity and neural signaling
- Changes in behavioral parameters: Modulation of neural circuits associated with motivation and behavioral responses in animal models
- Increased neuronal signaling: Observed in studies focusing on neuroendocrine pathways and hypothalamic function
PT-141 – Storage, Safety & References
- Storage Instructions: Keep PT-141 lyophilized at –20°C or lower in a dry, light-protected location. After reconstitution, store at 2–8°C and use within 30 days to maintain peptide integrity. Avoid repeated freeze-thaw cycles to preserve stability.
- Handling Safety: When handling PT-141, follow standard laboratory safety protocols. Wear appropriate personal protective equipment (PPE), including gloves, lab coats, and eye protection. The product is for laboratory research use only and should not be administered for human or veterinary use outside authorized clinical research settings.
- Disposal: Refer to institutional guidelines and dispose of any unused material in accordance with local regulations.
References
https://pubmed.ncbi.nlm.nih.gov/12851303
https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735
https://onlinelibrary.wiley.com/doi/10.1002/j.1939-4640.2004.tb02842.x
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/210557Orig1s000OtherR.pdf
https://pubmed.ncbi.nlm.nih.gov/17584130
https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464
Compliance Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use outside of authorized clinical research settings.