Sermorelin (5mg) About This Product
Sermorelin (5mg) is a synthetic sermorelin peptide supplied as a lyophilized powder containing 5 mg per vial for controlled laboratory and preclinical research. Sermorelin is a 29-amino-acid analog of human growth hormone–releasing hormone (GHRH), corresponding to the biologically active N-terminal fragment (residues 1–29) of the native 44-amino-acid GHRH molecule.
The peptide has an empirical formula of C₁₄₉H₂₄₆N₄₄O₄₂S and an average molecular weight of approximately 3,357.9 g/mol. A C-terminal amide modification is incorporated to enhance molecular stability during experimental handling. Research-grade Sermorelin is typically manufactured to ≥98–99% purity, verified by HPLC, with molecular identity confirmed by mass spectrometry.
In published research, Sermorelin has been investigated as a growth hormone secretagogue, primarily to evaluate pituitary growth hormone reserve, age-associated changes in GH secretion, metabolic regulation, body composition, and related endocrine parameters. The 5 mg vial format supports the preparation of multiple experimental concentrations in accordance with reported research protocols.
Sermorelin (5mg) Key Features and Benefits
- Defined peptide structure: Synthetic 29-amino-acid GHRH analog corresponding to the active N-terminal segment of native human GHRH
- High analytical purity: Typically produced at ≥98–99% purity, with identity confirmed by mass spectrometry
- 5 mg lyophilized vial: Supports flexible preparation across microgram-to-milligram research ranges
- Relevant research scope: Studied in GH stimulation, pituitary diagnostics, metabolic research, body composition, and neuroendocrine signaling
- Stable formulation: Lyophilized presentation enhances shelf stability under recommended storage conditions
- Consistent handling profile: Soluble in common aqueous laboratory diluents using standard techniques
- Research-focused distribution: Suitable for institutions that order sermorelin peptide for regulated laboratory investigation
- For laboratory research use only
Sermorelin (5mg) Mechanism & Research Applications
Sermorelin is researched as a functional analog of endogenous GHRH that stimulates pulsatile growth hormone release from anterior pituitary somatotroph cells. By promoting endogenous hormone secretion rather than supplying exogenous GH, Sermorelin allows researchers to study physiological GH dynamics while preserving native hypothalamic–pituitary feedback mechanisms.
Reported research applications include:
- Growth hormone reserve testing: Used as a provocative agent to evaluate pituitary responsiveness via measured GH release
- Age-related endocrine changes: Investigated in adult populations examining declining GH and IGF-1 associated with aging
- Metabolic regulation: Studied for effects on lipid metabolism, insulin sensitivity, and energy balance markers
- Body composition research: Examined in relation to lean mass, fat distribution, and nitrogen balance
- Neuroendocrine signaling: Used to study hypothalamic–pituitary communication and hormonal feedback regulation
- Oncology-related exploration: Preliminary studies have examined activity in glioma research models, focusing on cell-cycle and immune-related signaling
Researchers who buy sermorelin peptide should note that all applications described are investigational only and conducted within approved research protocols.
Sermorelin (5mg) Dosing & Observed Effects in Research
The following information summarizes dosing frameworks reported in published studies and is provided strictly for research context.
- Diagnostic research: Intravenous single-bolus administration at 1 mcg/kg, with serial blood sampling over 60–90 minutes to assess GH response
- Subcutaneous administration (pediatric studies): Daily doses around 30 mcg/kg, administered once daily or in divided doses
- Adult metabolic and endocrine studies: Daily doses commonly ranging from 0.2–0.5 mg, often administered in the evening
- Short-term metabolic and body-composition studies: Daily doses of 200–500 mcg over several weeks
- Combination research protocols: Lower per-dose quantities administered multiple times daily alongside other GH-releasing peptides
The 5 mg vial format supports dose-response experiments, comparative protocol design, and repeated test dosing under controlled laboratory conditions.
Sermorelin (5mg) Storage, Safety & References
Sermorelin (5mg) should be stored as a lyophilized powder in a tightly sealed vial, protected from light and moisture. For long-term stability, storage at –20°C or lower is recommended. Vials should be removed from cold storage only briefly during handling or aliquoting.
After reconstitution with sterile water, saline, or an appropriate aqueous buffer, solutions should be stored at 2–8°C and protected from light. Repeated freeze–thaw cycles should be avoided, and solutions showing discoloration or particulates should be discarded.
As a biologically active peptide, Sermorelin must be handled using standard laboratory safety procedures, including appropriate personal protective equipment. Disposal of unused material and contaminated consumables should follow institutional and regulatory research-waste guidelines.
References
https://pubmed.ncbi.nlm.nih.gov/18031173
https://academic.oup.com/jcem/article/82/5/1472/2823341
https://pmc.ncbi.nlm.nih.gov/articles/PMC2699646
https://academic.oup.com/edrv/article/19/2/203/2530830
https://pmc.ncbi.nlm.nih.gov/articles/PMC8165022
Compliance Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use.