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Buy Thymosin Alpha-1 Online

Thymosin Alpha-1 is a laboratory-produced form of a naturally occurring thymic peptide examined in immunological research. Research suggests it may affect T-cell development and immune signaling by modulating cytokine activity and innate immune responses, supporting studies of immune regulation mechanisms.

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General info
Brand

NOVERA COMPOUNDS
Strength

10mg
CAS

62304-98-7
Chemical Formula

C₁₂₉H₂₁₅N₃₃O₅₅
Molecular weight

3108.3 g/mol
Peptide Sequence

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Synonyms

Thymalfasin
Storage

Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life

24 months from the manufacturing date.

What Are The Purported Benefits of Thymosin Alpha-1?

Thymosin Alpha-1 peptide (Tα1) is a potent immune peptide recognized for its ability to enhance and regulate the immune system. It works by stimulating T-cell maturation and differentiation, strengthening the body’s natural defense mechanisms. Clinically, it has been used to support patients with chronic viral infections, such as Hepatitis B and C, and has been explored in severe COVID-19 cases for its immune-regulating effects.

Beyond viral defense, Thymosin Alpha-1 has shown promise as an adjuvant in cancer therapy, helping restore immune cell counts suppressed by chemotherapy or radiation, potentially improving patient outcomes. Studies also indicate that it can augment the immune response to vaccines in immunocompromised patients and provide antioxidant support by boosting cellular glutathione levels.

What Is the Chemical Makeup of Thymosin Alpha-1?

Thymosin Alpha-1 is a small, highly potent peptide consisting of 28 amino acids, designed for stability and reliable bioactivity. As a linear, acidic peptide with N-terminal acetylation, it is engineered to resist rapid degradation, making it suitable for laboratory and research use. It contains no aromatic, sulfur-containing, or carbohydrate structures, ensuring consistency in experimental applications.

  • Amino Acid Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
  • Molecular Mass: 3107.3 Da (monoisotopic mass)

Chemical Identifiers and Specifications

  • Chemical Formula: C₁₂₉H₂₁₅N₃₃O₅₅
  • Molecular Weight: 3108.3 g/mol
  • CAS Registry Number: 62304-98-7
  • PubChem Compound ID: 16130571
  • Purity: ≥99% HPLC
  • Synonyms: Thymalfasin
  • Appearance: Lyophilized white powder
  • Amino Acid Count: 28 amino acids
  • Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

What Does Scientific Research Say About Thymosin Alpha-1?

Thymosin Alpha-1 is one of the most rigorously studied immune peptides worldwide. It stimulates T-cell maturation, enhances dendritic cell activity, and regulates cytokine production through Toll-like receptors (TLR2 and TLR9).

  • Proven Clinical Use: Synthetic Tα1 (Thymalfasin) is approved in over 35 countries, primarily for the treatment of chronic hepatitis B, chronic hepatitis C, malignant melanoma, and DiGeorge syndrome with immune defects.
  • Dual Role in Immunity: Strengthens weak immune responses while preventing overactive inflammation during severe infections. This mechanism operates through coordinated effects on antigen-presenting cells and downstream T-cell programs. In dendritic cell systems, Tα1 engages Toll-like receptor-linked signaling pathways, promoting functional maturation phenotypes with enhanced Th1-associated cytokine profiles, while simultaneously promoting regulatory T-cell generation and anti-inflammatory signaling (IL-10 production). This balance enables immune enhancement during immunodeficiency while preventing pathological inflammation during hyperactive immune states.
  • Cancer Adjuvant: Research shows improved outcomes when used with chemotherapy or immunotherapy in select cancers, including melanoma and lung cancer.

Researchers can buy Thymosin Alpha-1 for research to explore these immune-enhancing properties in cutting-edge studies.

What Are the Storage Conditions for Thymosin Alpha-1?

Proper storage is essential to maintain Thymosin Alpha-1’s potency and effectiveness. In its lyophilized powder form, it is most stable when stored at –20°C (–4°F) and protected from moisture and light, allowing long-term storage.

Once reconstituted with sterile or bacteriostatic water, the solution must be refrigerated at 2–8°C and used within 2–4 weeks when using bacteriostatic water, as potency decreases rapidly at room temperature. Following these guidelines ensures that the Thymosin immune peptide remains effective for both research and clinical applications.

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This product is supplied strictly for laboratory research use only and is not approved for human or veterinary administration. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines. By purchasing or using this material, the buyer confirms that they are a qualified researcher and that the product will be used exclusively in controlled research settings compliant with all applicable regulations.

Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025

https://pmc.ncbi.nlm.nih.gov/articles/PMC1986709

https://pubmed.ncbi.nlm.nih.gov/8809225

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1237978/full