Healthy skin is constantly renewing itself. Through a natural process called desquamation, old skin cells are shed and replaced with fresh ones, keeping the surface smooth and protected. When this renewal cycle slows down or becomes disrupted, the skin can start to appear dull, flaky, or irritated, indicating that it may require additional support.
BioRePeel is designed to do just that. This innovative biphasic, needle-free chemical peel works in harmony with the skin’s natural rhythms, gently exfoliating while delivering active ingredients that brighten, hydrate, and rejuvenate. What sets it apart is its ability to achieve visible results with minimal discomfort and little to no downtime, making it an appealing option for patients seeking effective yet noninvasive skin care.
In this article, we’ll walk you through the BioRePeel protocol and administration technique, explaining how the treatment works, what the application process involves, and the key factors that help ensure safe, consistent, and rewarding results.
Key Takeaways
- BioRePeel is most effective for patients with mild to moderate acne, pigmentation, early signs of aging, and dull skin. However, it should be avoided in cases such as pregnancy, isotretinoin use, aspirin allergy, or uncontrolled medical conditions.
- Patients should avoid retinoids, exfoliants, and excessive sun exposure for 7–14 days before treatment to maximize safety and results.
- Shaking the ampoule, protecting sensitive areas, applying the solution evenly, and keeping it on for 3–5 minutes on the face or 5–10 minutes on the body ensures proper technique.
- Most patients benefit from 4–6 sessions spaced 7–10 days apart, with maintenance treatments every 2–3 months to preserve improvements.
- BioRePeel can be combined with microneedling, LED therapy, or injectables when used in conjunction with proper timing and supported by thorough aftercare.
- Daily SPF, avoiding makeup for 24 hours, and refraining from heat, sweat, or sauna use for 72 hours are essential components of recovery and achieving long-term results.
About: Medical Spa RX provides medical practices with premium products at the best prices. If you’re looking to buy BioRePeel online for your practice, the sales representatives at Medical Spa RX can give you guidance.
Patient Selection and Pre-Treatment Preparation for BioRePeel
Not every patient is an ideal candidate for BioRePeel. Those who benefit most often struggle with mild to moderate acne, early photoaging, fine lines, or dull, uneven skin. Patients with active infections, open wounds, uncontrolled skin conditions, or recent sunburn should not undergo treatment. Additional contraindications include pregnancy, breastfeeding, recent isotretinoin use, aspirin allergy, uncontrolled diabetes, or a history of keloid formation.
A thorough consultation is essential to set realistic expectations and create a safe treatment plan. Before the session, patients are advised to avoid sun exposure, exfoliating agents, retinoids, or other aggressive skincare products for 7 to 14 days. Skin should be thoroughly cleansed on the day of the procedure.
Pre-treatment preparation also involves explaining the process, possible side effects, and detailed BioRePeel aftercare instructions so patients feel confident and ready for the treatment.
Step-by-Step Application Technique for BioRePeel
A precise application technique is key to ensuring safe, consistent, and effective outcomes. Each stage should be carried out carefully for maximum comfort and results.

- Shake Ampoule: Always shake the BioRePeel ampoule before use to mix the biphasic solution properly.
- Cleanse and Degrease: Begin by thoroughly cleansing the skin to remove impurities. Apply a degreasing solution to eliminate sebum, allowing better penetration.
- Protect Sensitive Areas: Apply a thin layer of petroleum jelly or barrier cream to areas like the lips, nostrils, and corners of the eyes.
- Apply Solution: Wear gloves and apply the BioRePeel solution evenly using sterile gauze or a brush. Spread in light, controlled strokes for consistent coverage.
- Observe the Reaction: Leave the solution on for 3–5 minutes on the face and 5–10 minutes on the body, monitoring closely for redness, stinging, or sensitivity.
- Massage and Remove: Gently massage the treated area to encourage absorption, then rinse thoroughly with water (or a neutralizing solution if preferred).
- Post-Treatment Care: Apply calming serums, fragrance-free moisturizers, and sunscreen to soothe and protect the skin.
Following this structured process helps minimize irritation while supporting smooth, predictable results.
Treatment Frequency and Number of Sessions for BioRePeel
The ideal number of BioRePeel sessions depends on the patient’s skin type, condition, and treatment goals. In most cases, a series of four to six sessions spaced 7 to 10 days apart delivers visible improvements in clarity, smoothness, and radiance. This schedule balances effectiveness with safety, allowing the skin time to renew between sessions.
After the initial series, patients may get maintenance sessions every two to three months, particularly for those managing recurring acne, pigmentation, or early signs of aging. Regular upkeep enhances long-term results by stimulating collagen production and encouraging ongoing cell turnover.
When building a treatment plan, providers should individualize frequency based on:
- Age and baseline skin type
- Severity of the targeted concern
- History of chemical peels or other aesthetic treatments
- Patient’s desired timeline for improvements
Combining BioRePeel with Other Aesthetic Treatments
BioRePeel can be safely combined with other non-invasive treatments to enhance overall results. Its exfoliating and regenerative effects create an ideal foundation for complementary procedures, but careful planning and spacing are crucial.

Popular Combinations
- Microneedling: Freshly exfoliated skin absorbs serums and growth factors more effectively, enhancing collagen stimulation.
- LED Therapy: Helps minimize post-peel inflammation and speeds skin recovery.
- Fillers or Botox: BioRePeel improves surface texture, while injectables target deeper lines or volume loss. However, it’s best to space peels and injectables at least 1–2 weeks apart to reduce irritation and support healing.
When combining treatments, providers should evaluate each patient’s skin type, tolerance, and goals. Following proper protocols and strict aftercare supports optimal results. Patients should avoid makeup for at least 24 hours, refrain from sweating, saunas, or hot showers for 72 hours, and commit to daily SPF use to protect new skin. With these measures in place, combining BioRePeel with other therapies can deliver natural, long-lasting improvements.
Conclusion
The BioRePeel protocol offers a safe, minimally invasive approach to skin rejuvenation when performed with careful screening, proper technique, and consistent scheduling. By understanding patient suitability, following precise application steps, and reinforcing thorough aftercare, clinicians can deliver reliable results with minimal downtime.
When combined with complementary aesthetic treatments, BioRePeel can further enhance outcomes. Provided timing, aftercare, and patient safety remain the top priorities. For patients, this means healthier, smoother, and more radiant skin that feels refreshed and revitalized.
FAQs
1. How do you apply BioRePeel correctly?
Cleanse and degrease the skin, protect sensitive areas, apply the solution evenly, observe reaction, then neutralize and apply aftercare.
2. How many BioRePeel sessions are recommended?
Most patients require four to six sessions spaced one week apart, with maintenance treatments every two to three months.
3. Can a patient get a combination treatment of BioRePeel and microneedling?
Yes, BioRePeel with microneedling is common, as it enhances absorption of active ingredients and stimulates collagen effectively.
4. Who should avoid BioRePeel treatments?
Patients with active infections, open wounds, severe skin sensitivity, or uncontrolled skin conditions should not undergo this procedure.
5. What aftercare is important following BioRePeel?
Patients should avoid sun exposure, harsh skincare products, and exfoliants, while using gentle cleansers, moisturizers, and sunscreen daily.
References
Zani MB, Sant’Ana AM, Tognato RC, Chagas JR, Puzer L. Human tissue Kallikreins-Related peptidases are targets for the treatment of skin desquamation diseases. Frontiers in Medicine. 2022;8. doi:10.3389/fmed.2021.777619
Pierard GE, Goffin V, Hermanns-Le T, Pierard-Franchimont C. Corneocyte desquamation. International Journal of Molecular Medicine. Published online August 1, 2000. doi:10.3892/ijmm.6.2.217