SESDERMA®

About SESDERMA®: Spanish Professional Skincare with Liposomal Technology

SESDERMA® was founded in 1989 in Valencia, Spain, where it remains headquartered and manufactured today. Where are SESDERMA® products made? Entirely in the company’s own EU-compliant facilities in Valencia, which gives the brand direct control over formulation quality and regulatory compliance rather than relying on third-party contract manufacturing.

The brand sits in the professional cosmeceutical category, distributed through aesthetic clinics, dermatology practices, and medical spas globally rather than general retail. What separates SESDERMA® products from typical over-the-counter skincare is the delivery system behind the formulas: liposomal encapsulation that carries active ingredients such as vitamin C, azelaic acid, retinol, and growth factors into deeper skin layers through membrane fusion with skin cells.

SESDERMA® also uses the NANOPORE professional device line, MEDIDERMA®’s microneedling system (NANOPORE Stylus and Pen), as a complementary in-clinic tool for improving topical active penetration. This combination of liposomal delivery at home and NANOPORE microneedling in clinic is the brand’s core clinical differentiator, and it is the reason practitioners often recommend SESDERMA® over standard topical cosmetics when active ingredient delivery actually matters to the treatment outcome.

SESDERMA® Liposomal and NANOPORE Technology: Why It Matters Clinically

Tiny phospholipid vesicles known as liposomes, usually measuring between 100 and 400 nanometers, trap active compounds to shield them during transit to the skin. Upon touching the surface, these carriers merge with cell membranes and empty their payload directly inside the cells. Scientific literature confirms this process significantly enhances how well cosmetic ingredients penetrate the skin relative to standard topical bases. [1] This overarching nanotech strategy has defined SESDERMA® ever since the firm introduced its initial nanotechnology-driven items back in 2008.

The NANOPORE® system (branded across several of MEDIDERMA®’s professional lines) complements this by using electric microneedling hardware, such as the NANOPORE Stylus, to create micro-channels directly through the stratum corneum, the skin’s main barrier layer. Peer-reviewed research confirms that combining mechanical micro-channeling with nano-scale lipid carriers significantly enhances the permeation of active molecules like vitamin C, azelaic acid, and retinol compared to standard topical applications alone.[4]

Clinicians deal with a simple reality: the active concentrations stated on SESDERMA® product labels reflect the amount penetrating deep into the skin rather than remaining on the outer barrier. This performance gap explains why the company markets its antioxidant and liposomal serums as therapeutic treatments instead of standard beauty products.

SESDERMA® Product Ranges: Full Catalog Overview

Sesderma’s catalog is organized by range, with each line built around a specific active complex and treatment goal. Beyond the core products detailed below, the wider catalog also includes the SESDERMA® SESLASH lash-conditioning serum, the intensive SESDERMA® HIDRADERM TRX line, SESDERMA® NANOCARE intimate for intimate skin care, the SESDERMA® SALISES range for oily and acne-prone skin, RETISIL INTENSIVE for advanced anti-aging support, and SESDERMA® shampoo formulations for scalp health.

AZELAC® RU Range (pigmentation, post-inflammatory hyperpigmentation, melasma)

• SESDERMA® AZELAC® RU LIPOSOMAL SERUM: A facial serum targeting uneven skin tone and post-inflammatory hyperpigmentation. This SESDERMA® AZELAC RU serum combines a multi-ingredient depigmenting complex, with key actives including azelaic acid, tranexamic acid, 4-butylresorcinol, and niacinamide, delivered through Sesderma’s liposomal system for enhanced epidermal penetration in sensitive skin.
• SESDERMA® AZELAC® RU LUMINOUS FLUID CREAM: A moisturizing facial cream version of the same depigmenting complex, formulated as a cream gel for patients who prefer a richer texture or have drier skin.

C-VIT Range (SESDERMA® vitamin C, antioxidant protection, brightening)

• SESDERMA® C-VIT LIPOSOMAL SERUM: The anchor of the SESDERMA® C-VIT antioxidant serum line, using liposomal encapsulation to improve on the penetration limits of conventional ascorbic acid formulas. It addresses oxidative stress, dullness, and uneven tone as part of brightening and anti-aging protocols. There is also a limited edition antioxidant version released periodically.
• SESDERMA® C-VIT MIST: A moisturizing facial mist with vitamin C, useful post-procedure or as a quick daily antioxidant and hydration boost.
• SESDERMA® C-VIT RADIANCE GLOWING FLUID: A lightweight, moisturizing antioxidant cream hybrid combining vitamin C with hydration for patients who want radiance without a heavy finish.

FACTOR G RENEW (growth-factor anti-aging)

• SESDERMA® FACTOR G RENEW REJUVENATING CREAM: An anti-aging facial cream built on growth factor technology, aimed at skin regeneration, lines and wrinkles, and loss of firmness. Frequently positioned for mature skin or as part of post-procedure regenerative protocols, and some practitioners pair it with a dedicated eye contour treatment for the periorbital area.

HIDRADERM Range (deep hydration)

• SESDERMA® HIDRADERM HYAL FACIAL CREAM: A hyaluronic acid-based moisturizing facial cream for intensive hydration and skin barrier support, well suited to dry, dehydrated, or sensitive skin, and often used as topical maintenance between injectable HA sessions.

HIDRAVEN Range (gentle, sensitive-skin cleansing)

• SESDERMA® HIDRAVEN FOAMY SOAP-FREE CREAM: A gentle, soap-free cleansing cream built for skin prone to dryness or intolerance, compatible with most cosmetic and post-procedure protocols where a mild cleanser is required.

REPASKIN Range (daily sun protection)

• SESDERMA® REPASKIN INVISIBLE FLUID SPF50+: A broad-spectrum SPF50+ sunscreen in a lightweight, invisible fluid finish, positioned as daily photoprotection for aesthetic patients. SESDERMA® REPASKIN is considered essential after laser treatments, peels, and pigmentation protocols where UV exposure can reverse clinical progress.

Is SESDERMA® Medical Grade?

Operating in the space between standard cosmetics and drugs, SESDERMA® is a cosmeceutical brand, positioned between standard over-the-counter cosmetics and pharmaceutical products rather than in either category outright.

• Higher active ingredient concentrations than typical retail cosmetics
• Distribution limited to professional channels: clinics, aesthetic practices, and dermatologists
• Advanced delivery technology (liposomes, NANOPORE) not commonly found in mass-market skincare
• Regulated as a cosmetic product under the EU Cosmetics Regulation (EC) No 1223/2009, not as a pharmaceutical, and not available by prescription[2]

SESDERMA® belongs to the professional skincare category, leaning closer to clinical efficacy than typical retail beauty, yet lacking the formal classification of a medication or medical device.

SESDERMA® Compared to Other Professional Skincare Brands

SESDERMA® vs. Mesoestetic

MESOESTETIC, also based in Spain, is widely regarded as one of the more established medical-grade professional skincare brands in the Spanish market, with a stronger footprint in dermatology clinics and a more extensively published clinical evidence base. Its Cosmedical range is positioned firmly at the prescription-adjacent, professional end of skincare. SESDERMA®, by comparison, spans a broader professional-to-consumer spectrum, with liposomal delivery technology as its primary point of differentiation rather than clinical publication volume.

Head-to-head, Mesoestetic’s radiance DNA fluid competes with Sesderma’s C-VIT range in the antioxidant and brightening space, and its brightening lines compete directly with SESDERMA® AZELAC® RU in pigmentation. Sesderma’s advantage tends to be its delivery technology story; Mesoestetic’s advantage tends to be depth of clinical evidence.

SESDERMA® vs. Fillmed

FILLMED®, part of the Filorga group in France, positions itself primarily as a professional injectable and mesotherapy brand, with its NCTF® nutritive cocktail range as the flagship product line. Its topical skincare, sold under the ART FILLER name, sits closer to the premium consumer space than the clinical professional tier SESDERMA® occupies. The more useful comparison point is pre- and post-procedure skincare protocols: FILLMED®’s topical offering is narrower than SESDERMA®’s, which spans pigmentation, vitamin C, sun protection, hydration, and retinol in one catalog. FILLMED® carries stronger name recognition specifically among injectors, while SESDERMA® offers greater product range depth and a clearer delivery-technology differentiator.

SESDERMA® vs. BCN (Institut BCN)

Institut BCN, based in Barcelona, is fundamentally a mesotherapy brand, built around injectable cocktails rather than topical skincare. Its topical offering exists but is secondary to its injectable protocols. SESDERMA® operates entirely in the topical category, so the comparison is less about which brand is better and more about how they complement each other. Many practitioners pair BCN injectable mesotherapy with Sesderma’s topical maintenance products as part of a single aesthetic protocol rather than choosing one over the other.

SESDERMA® vs. MEDIDERMA®

Clinicians are the exclusive buyers of MEDIDERMA, keeping it restricted to professional settings and aligned with a medical standard. Conversely, SESDERMA® reaches a broader audience through professional networks alongside direct-to-consumer availability in multiple regions. When professionals weigh these brands, the decision usually hinges on whether treatments are meant strictly for in-office procedures (MEDIDERMA®) or if patients need take-home maintenance options (SESDERMA®). A number of practices choose to carry both lines.

SESDERMA® vs. Plinest

PLINEST, made by Mastelli in Italy, is a polynucleotide (PDRN) injectable, which puts it in an entirely different product category from Sesderma’s topical skincare. Plinest works through injectable skin regeneration; SESDERMA® is applied topically, so the two function as complementary parts of the same protocol rather than direct competitors. Practitioners running Plinest injectable biostimulation often pair it with SESDERMA® topical products, particularly REPASKIN SPF50+ for post-procedure photoprotection, HIDRADERM HYAL for barrier support, and C-VIT antioxidant serum for skin protection between sessions.

Key Indications — Where SESDERMA® Products Fit Aesthetic Protocols

SESDERMA® offers targeted skincare solutions that can be incorporated into a wide range of aesthetic treatment protocols. Common clinical applications include:

• Pigmentation protocols: Pair AZELAC® RU Liposomal Serum with REPASKIN SPF50+ to address hyperpigmentation while providing the daily photoprotection needed to reduce the risk of rebound pigmentation. SESDERMA® HIDRADERM TRX may also be incorporated into selected brightening regimens.
• Post-injectable maintenance: HIDRADERM HYAL provides topical hyaluronic acid support between injectable HA treatments, while C-VIT antioxidant serum helps protect the skin from environmental oxidative stress during recovery. An antioxidant cream may also be added to reinforce barrier function based on individual patient needs.
• Post-laser and post-peel care: HIDRAVEN Foamy Soap-Free Cream offers gentle cleansing after procedures, REPASKIN Invisible Fluid SPF50+ delivers essential daily sun protection, and FACTOR G RENEW supports skin regeneration throughout the healing process.
• Anti-aging protocols: FACTOR G RENEW, the SESDERMA® RETI AGE (SESDERMA® retinol) range, and C-VIT can be layered as part of a broader anti-aging routine. Additional products, including RETISIL INTENSIVE, selected cream gel formulations, and eye contour treatments, can be incorporated to address specific concerns. In our experience, clinics that run a layered SESDERMA® anti-aging protocol tend to find the product pairing straightforward precisely because each range is designed to complement the others rather than overlap.

Where to Buy SESDERMA® in the USA

Medical Spa Rx supplies SESDERMA® products to licensed aesthetic practitioners across the United States, with the full catalog available online for verified accounts.

We carry wholesale pricing across the AZELAC® RU, C-VIT, FACTOR G RENEW, HIDRADERM, HIDRAVEN, and REPASKIN ranges, with practices able to buy SESDERMA® wholesale on bulk orders. Medical Spa Rx provides a single online source so practices do not have to piece together SESDERMA® products from multiple importers, with reliable shipping to licensed clinics nationwide and tracking on every order. Both one-off and recurring wholesale orders are supported as a practice’s stock needs change.

If you are ready to buy SESDERMA® online, browse the full range above, add products to your cart, or contact the Medical Spa Rx team directly to order SESDERMA® online or discuss bulk pricing and shipping timelines.

Safety and Tolerability

SESDERMA® products are manufactured in the EU and formulated to meet the safety assessment requirements of the EU Cosmetics Regulation (EC) No 1223/2009. [2] Liposomal formulations are generally well tolerated across skin types, though a few product-specific precautions apply.

• AZELAC® RU: avoid in patients with known azelaic acid sensitivity. Peer-reviewed evidence supports azelaic acid’s efficacy and safety profile across pigmentation and inflammatory skin conditions, with mild, transient irritation as the most commonly reported side effect. [3]
• REPASKIN: uses broad-spectrum UV filters compliant with EU cosmetics regulation.
• Retinol range (SESDERMA® RETI AGE, SESDERMA® retinol): standard retinol precautions apply, including avoiding use during pregnancy, requiring daily sun protection, and introducing the product gradually in sensitive skin.

SESDERMA® also maintains a cruelty-free policy and does not test finished products on animals.

Storage and Handling

Store SESDERMA® products at room temperature, below 25°C (77°F), and protect them from direct sunlight and excessive heat to help maintain product stability. Keep containers tightly closed between uses to minimize exposure to air and contaminants. Unlike injectable products, SESDERMA® topical formulations do not require cold-chain storage, making them convenient for routine clinic and home use. For optimal performance and safety, always use each product before the expiration date printed on its label.

Frequently Asked Questions

What is SESDERMA®?

SESDERMA® is a professional cosmeceutical skincare brand established in 1989 in Valencia, Spain. It uses proprietary liposomal delivery technology and partners with MEDIDERMA®’s NANOPORE microneedling devices to improve active ingredient penetration, with product ranges spanning pigmentation, vitamin C, anti-aging, hydration, sun protection, retinol, and sensitive skin care.

Where are SESDERMA® products made?

SESDERMA® manufactures all products at its own facilities in Valencia, Spain, under EU cosmetic regulations including Regulation (EC) No 1223/2009. Production is kept in-house rather than contracted to third parties.

Is SESDERMA® medical grade?

SESDERMA® is a cosmeceutical brand with higher active concentrations and advanced delivery technology compared to standard OTC skincare, but it is regulated as a cosmetic product under EU law, not as a pharmaceutical. It is sold through professional channels rather than by prescription.

Are SESDERMA® and MEDIDERMA® the same?

They share a parent company, SESDERMA® Group S.L., but serve different purposes. MEDIDERMA® is the clinic-exclusive professional arm formulated strictly for in-practice use, while SESDERMA® spans professional and consumer-accessible channels with a broader product portfolio.

What is SESDERMA®’s liposomal technology?

Sesderma’s liposomal system uses phospholipid vesicles to transport active ingredients like vitamin C, azelaic acid, and retinol past the skin surface and release them intracellularly. This improves bioavailability compared with conventional topical formulations, and it is the core technology behind the brand’s clinical positioning.

What is SESDERMA® AZELAC® RU?

Sesderma’s primary pigmentation correction range, formulated around a depigmenting complex that includes azelaic acid, tranexamic acid, 4-butylresorcinol, and niacinamide. It is available as a liposomal serum and a luminous fluid cream and is commonly used for post-inflammatory hyperpigmentation, melasma, uneven tone, and rosacea-related redness.

Where to buy SESDERMA® products in the USA?

Licensed aesthetic practitioners in the United States can buy SESDERMA® products through Medical Spa Rx. The platform offers the complete SESDERMA® catalog with options for both individual and wholesale orders, secure online checkout, and add-to-cart ordering. Browse the product range above or contact the team to buy SESDERMA® wholesale and request pricing information.

The page and all of its displayed contents are for medical professionals, designed to inform only, and not as a replacement for medical advice.

References

[1] Lens M. Phospholipid-Based Vesicular Systems as Carriers for the Delivery of Active Cosmeceutical Ingredients. Int J Mol Sci. 2025;26(6):2484. Published 2025 Mar 11. doi:10.3390/ijms26062484 

[2] EUR-Lex. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. https://eur-lex.europa.eu/eli/reg/2009/1223/oj/eng

[3] King S, Campbell J, Rowe R, Daly ML, Moncrieff G, Maybury C. A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. J Cosmet Dermatol. 2023;22(10):2650-2662. doi:10.1111/jocd.15923 

[4] Yu YQ, Yang X, Wu XF, Fan YB. Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications. Front Bioeng Biotechnol. 2021;9:646554. Published 2021 Mar 29. doi:10.3389/fbioe.2021.646554

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Written and reviewed by the Medical Spa Rx Editorial Team 

All clinical and product claims on this page have been checked against peer-reviewed research, manufacturer data, and regulatory sources in accordance with our Editorial Policy .