As the body’s largest organ, the skin is a vital barrier against environmental stressors while maintaining hydration, temperature regulation, and overall health. However, with age, the skin undergoes structural changes: collagen depletion, reduced elasticity, and slower cellular renewal—leading to visible signs of aging and increased sensitivity.
Mastelli, an Italian pharmaceutical company, has pioneered regenerative medicine. With decades of expertise in biotechnology and tissue repair, Mastelli focuses on developing innovative solutions that restore the skin’s vitality at a cellular level. One of its most notable contributions is Plinest, a polynucleotide-based injectable designed for long-term rejuvenation. Backed by scientific research and clinical application, Plinest exemplifies Mastelli’s commitment to advancing safe, effective treatments that support skin health and aesthetic enhancement.
This article will explore Mastelli’s legacy, the science behind Plinest, and its impact on modern aesthetic medicine.
Key Takeaways
- Mastelli is an Italian pharmaceutical company specializing in regenerative medicine and aesthetic dermatology, particularly through polynucleotide-based treatments.
- The company’s flagship innovations include the PLINEST® and NEWEST® lines. These combine polynucleotides and hyaluronic acid to enhance skin repair, hydration, and elasticity.
- Plinest utilizes PN-HPT (Polynucleotides High Purification Technology) to deliver highly purified DNA fragments that stimulate fibroblast activity. This leads to improved collagen production, tissue repair, and skin rejuvenation.
- Key differentiators of Plinest include its non-crosslinked formulation, which ensures natural tissue integration and minimizes risks of nodules or overcorrection.
- Mastelli maintains a global presence in over 40 countries, supported by CE-certified products, ISO-compliant manufacturing, and a strong focus on regulatory compliance and quality control.
- The company invests heavily in research and development. It conducts clinical trials, publishes in scientific journals, and continuously improves product formulations and treatment protocols.
- Through post-market surveillance and advanced purification technologies, Mastelli ensures the safety and efficacy of its products, reinforcing its leadership in non-invasive regenerative treatments.
- Mastelli’s collaboration with universities, dermatologists, and research institutions contributes to ongoing innovations in tissue regeneration and aesthetic medicine.
- With its combination of scientific rigor, global reach, and commitment to natural skin regeneration, Mastelli stands out as a trusted manufacturer in the aesthetic industry.
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Mastelli’s History and Expertise in Aesthetic Medicine
Founded in 1952, Mastelli has established itself as a pioneer in regenerative medicine and aesthetic dermatology. Headquartered in Italy, the company has specialized in developing polynucleotide-based treatments and has created Class III medical devices designed for skin rejuvenation and anti-aging solutions.
Over the decades, Mastelli has refined its expertise in crafting intradermal revitalizers, with product lines such as PLINEST® and NEWEST®. These products combine Polynucleotides with Hyaluronic Acid to enhance skin repair, hydration, and elasticity.
Mastelli roots its innovation in a strong commitment to biocompatibility and cellular regeneration. Their proprietary PN-HPT (Polynucleotides High Purification Technology) ensures the delivery of highly purified DNA fragments that actively support tissue repair while minimizing the risk of adverse reactions. The company designs formulations to address common aging concerns while actively promoting natural skin renewal, positioning Mastelli as a leader in regenerative aesthetics.
With a strong emphasis on research, safety, and clinical efficacy, Mastelli continues to evolve its product portfolio, providing cutting-edge solutions that uphold the highest quality standards for medical professionals and patients worldwide.
Innovation Behind Plinest by Mastelli
For those asking, what is Plinest?—it is Mastelli’s flagship injectable treatment developed to support natural skin regeneration through polynucleotide-based biostimulation. Plinest utilizes PN-HPT technology to deliver highly purified polynucleotides derived from trout DNA, designed to activate fibroblasts, thereby enhancing collagen and elastin production. This process significantly improves skin texture, hydration, and firmness, offering a gradual and natural rejuvenation effect.
Key attributes that differentiate Plinest:
- PN-HPT Technology: Extracted from natural DNA sources and purified for optimal compatibility with human skin.
- Cellular Stimulation: Encourages fibroblast activity and extracellular matrix remodeling.
- Hydration and Elasticity: Improves skin texture, thickness, and elasticity over time.
- Non-Crosslinked Formulation: Ensures a more natural integration with tissue, minimizing the risk of nodules or overcorrection.
- Safe Profile: Designed with minimal additives, reducing the risk of hypersensitivity or adverse reactions.
Unlike conventional dermal fillers, Plinest’s regenerative mechanism makes it an ideal solution for treating fine lines, acne scars, skin laxity, and photoaging, providing long-term skin health improvements rather than temporary cosmetic effects.
Global Reach and Regulatory Compliance of Mastelli Plinest
Mastelli’s impact extends well beyond its Italian roots, with a global presence in over 40 countries. This widespread adoption reflects not only the efficacy of its products but also its dedication to stringent regulatory compliance and quality assurance.
Key pillars of Mastelli’s global success include:
- CE Certification: All Plinest products bear the CE mark, confirming compliance with EU health, safety, and environmental protection directives.
- International Expansion: Distributors register and deliver Mastelli products across Europe, the Middle East, Latin America, and parts of Asia.
- Quality Control: Their manufacturing processes follow ISO-certified quality standards.
- Medical Device Classification: Authorities regulate Plinest as a medical device, requiring continuous documentation and post-market surveillance.
- Training and Education: Mastelli supports international practitioners with medical training and application techniques for optimal results.
Mastelli’s ability to maintain high product standards across diverse international markets speaks to the robustness of its manufacturing and oversight processes, reinforcing its credibility in the global aesthetic industry.
Mastelli’s Commitment to Research and Development
At the heart of Mastelli’s success is its unwavering dedication to research and development (R&D). The company continuously invests in scientific research to refine its formulations, explore new applications, and ensure that its products align with evolving clinical needs and aesthetic expectations.
Core aspects of Mastelli’s R&D efforts include:
- Clinical Trials: Regularly conducted to assess product efficacy, tolerability, and patient satisfaction.
- Scientific Publications: Researchers publish results in peer-reviewed journals, strengthening contributions to the scientific community.
- Product Improvements: The company continually explores new formulations and application techniques.
- Safety Monitoring: Post-market data collection helps refine usage protocols and enhance patient safety.
- Technology Advancement: Ongoing innovation in polynucleotide purification and delivery systems.
Mastelli’s R&D initiatives not only strengthen the Plinest product line but also support broader advancements in tissue regeneration, aesthetic medicine, and dermatology.
Conclusion
With a rich heritage dating back to 1952, Mastelli has earned its place as a leading force in regenerative medicine and aesthetic dermatology. Its innovative PN-HPT technology and the development of Plinest mark significant contributions to the field of non-surgical skin rejuvenation, offering solutions grounded in cellular regeneration rather than superficial correction.
Mastelli’s global footprint, adherence to strict regulatory standards, and commitment to scientific excellence have positioned the company as a trusted partner for practitioners worldwide. The Plinest range, known for its purity, biological compatibility, and proven clinical outcomes, remains a top choice for those seeking safe, effective, and long-lasting skin revitalization treatments.
Through continued investment in research, education, and innovation, Mastelli reinforces its mission to provide advanced regenerative solutions, shaping the future of aesthetic medicine.
FAQs
1. What is Plinest used for?
Plinest improves skin texture, elasticity, and hydration. It also helps treat fine lines, acne scars, and dull or aging skin.
2. How does Plinest work?
Plinest contains highly purified polynucleotides that stimulate fibroblast cells to regenerate the skin’s structure and restore elasticity.
3. How many Plinest sessions are typically needed?
A course typically involves 3–4 sessions spaced 2–3 weeks apart. Depending on individual skin needs, maintenance sessions may follow.
4. Is Plinest safe for all skin types?
Yes, it is biocompatible and generally safe for all skin types. Professionals always recommend a consultation before beginning treatment.
5. What areas can be treated with Plinest?
Common treatment areas include the face, neck, décolleté, and hands. Practitioners can also apply it under the eyes and in other delicate zones.
6. Are there side effects from Plinest?
Minor swelling, redness, or bruising at the injection site may occur but usually resolves within 24–48 hours.
7. How soon can results be seen?
Most patients notice improved hydration and glow within a week. More significant structural improvements appear after several sessions.
References
Bonté F, Girard D, Archambault JC, Desmoulière A. Skin Changes During Ageing. Subcellular Biochemistry. 2019;91(1):249-280. doi:https://doi.org/10.1007/978-981-13-3681-2_10
Skin Rejuvenation and Resurfacing. American Society of Plastic Surgeons. https://www.plasticsurgery.org/cosmetic-procedures/skin-rejuvenation-and-resurfacing
