Polynucleotides are becoming a game-changer in aesthetic medicine, prized for their remarkable ability to boost skin regeneration, enhance elasticity, and restore youthful vitality. At the forefront of this innovation is the Plinest product range, which expertly blends cutting-edge biotechnology with dermatological science to deliver powerful, targeted skincare solutions.

Designed to stimulate fibroblast activity, promote collagen synthesis, and deeply hydrate the skin, Plinest products tackle a variety of concerns—from fine lines and wrinkles to loss of firmness—making them a versatile choice for non-surgical skin rejuvenation.

This article provides a complete overview of the Plinest product range, breaking down their unique formulations, key benefits, and ideal applications to help practitioners and skincare enthusiasts discover the full potential of this advanced polynucleotide technology.

Key Takeaways

  • The Plinest product range is a polynucleotide-based line developed by Mastelli. It is aimed at skin and scalp rejuvenation through bio-revitalization and enhanced collagen production.
  • Each product targets specific concerns, including fine lines, wrinkles, dark circles, hair thinning, and skin hydration, offering tailored solutions within a personalized Plinest protocol.
  • Key formulations include Plinest Eye for delicate under-eye skin, Plinest Hair for early hair loss, Plinest Fast for rapid results, and Newest for combined hydration and regeneration.
  • The products use salmon DNA-derived polynucleotides known for their regenerative properties and compatibility with human tissue.
  • Packaging features sterile, pre-filled syringes designed for easy administration by medical professionals.
  • Clinical use shows effective results in improving skin elasticity, texture, and hydration, as well as promoting hair follicle health and density.
  • Understanding each product’s unique formulations and indications is essential to optimizing treatment outcomes and patient satisfaction.

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Overview of the Plinest Product Line

Plinest is a revolutionary polynucleotide-based skincare solution from Mastelli that can effectively rejuvenate and repair damaged skin. This advanced product line promotes bio-revitalization, stimulates fibroblast activity, and enhances collagen production to improve skin elasticity and hydration. Plinest’s range of specialized formulations, including Plinest Eye, Plinest Hair, and Plinest Fast, each designed to target distinct concerns such as wrinkles, dark circles, hair thinning, and overall skin texture.

syringe is filled

By leveraging the skin’s natural healing pathways, Plinest provides a natural, long-lasting anti-aging effect that calms inflammation and accelerates tissue repair. Its unique composition ensures deep hydration and skin regeneration, making it a preferred choice for those aiming to achieve a youthful, radiant complexion

Whether used as a preventive measure in younger skin or for regenerative purposes in mature skin, Plinest offers visible results backed by clinically proven efficacy. This comprehensive approach supports a tailored Plinest protocol, ensuring treatments are personalized to each patient’s needs.

Indications and Applications for Each Plinest Product

Each product within the Plinest line addresses specific aesthetic or regenerative needs. Below is a detailed breakdown of the common indications for each formulation:

  • Plinest: Used for treating superficial signs of aging such as fine lines, mild wrinkles, and loss of skin elasticity. Ideal for patients seeking an overall skin refresh.
  • Plinest Fast: Chosen when patients need quicker results, such as before a major event. It helps improve skin tone and radiance within a shorter time frame.
  • Plinest Eye: Specifically indicated for tired, dull, or aging periorbital skin. Effective in reducing puffiness, improving texture, and softening crow’s feet.
  • Plinest Hair: Recommended for early-stage hair loss, thinning, or poor scalp condition. It stimulates circulation and promotes better follicle health and hair density.
  • Plinest One: Suitable for use on large treatment zones, especially where widespread skin rejuvenation is needed. Often used on the neck, décolleté, arms, and abdomen.
  • Newest: Best suited for dehydrated or aging skin needing both structural improvement and hydration. Commonly applied to the face, neck, and hands.

Composition and Packaging Details

Each Plinest product features a unique formulation tailored to specific treatment goals. All products contain high-quality polynucleotides sourced from salmon DNA, known for their potent regenerative properties and excellent compatibility with human tissue. Here’s an overview:

smoother skin
  • Plinest and Plinest Fast: Contain high concentrations of PDRN (polydeoxyribonucleotide) for intensive skin regeneration.
  • Plinest Eye: Features a more diluted concentration to ensure safe use in sensitive periorbital tissues.
  • Plinest Hair: Includes polynucleotides and can work great with vitamins or peptides during mesotherapy protocols.
  • Plinest One: Offers a more diluted solution to treat large surface areas efficiently without causing heaviness.
  • Newest: Contains both polynucleotides and non-crosslinked hyaluronic acid for dual action—regeneration and hydration.

Packaging typically consists of sterile, pre-filled syringes (usually 2 mL), designed for easy and safe administration by licensed medical professionals. The convenience and precision of this packaging help optimize treatment efficacy and patient comfort.

Conclusion

The Plinest product range delivers a versatile and targeted approach to skin and scalp rejuvenation. By tailoring treatments to individual patient concerns—from facial aging and under-eye revitalization to scalp therapy and full-body biostimulation—Plinest offers flexibility and consistently effective results.

Clinicians must deepen their understanding of each product’s formulation, indications, and best practices to achieve optimal clinical outcomes. Whether addressing the delicate skin around the eyes or revitalizing large areas such as the neck and décolleté, the Plinest line provides scientifically backed options to support diverse aesthetic goals within a well-structured treatment plan.

FAQs

1. What are polynucleotides, and why are they used in Plinest products?

Polynucleotides are DNA fragments known for their tissue regeneration, anti-inflammatory, and moisturizing effects. They help improve skin structure and accelerate healing.

2. Is Plinest treatment safe for all skin types?

Yes, Plinest products are biocompatible and safe for all Fitzpatrick skin types when administered by a qualified professional.

3. How many sessions will a patient need for visible results?

Typically, patients should get 3–4 sessions spaced 2–3 weeks apart. They may need maintenance treatments every 6–12 months.

4. Can I combine Plinest with other aesthetic treatments?

Practitioners may use Plinest alongside procedures like laser therapy, microneedling, or dermal fillers to enhance outcomes.

5. Are there any side effects?

Side effects are minimal and may include temporary redness, swelling, or mild discomfort at the injection site.

6. Who should not receive Plinest treatments?

Patients who are pregnant, breastfeeding, or have severe autoimmune conditions should consult their healthcare provider before undergoing treatment.

7. How does Newest differ from standard Plinest products?

The latest combines polynucleotides with hyaluronic acid, making it more suitable for treating dehydrated skin that requires both repair and hydration.

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References

Lee KWA, Chan KWL, Lee A, et al. Polynucleotides in Aesthetic Medicine: A review of current practices and Perceived effectiveness. International Journal of Molecular Sciences. 2024;25(15):8224. doi:10.3390/ijms25158224

Webb WR, Rahman E, Rao P, et al. Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review. European Journal of Plastic Surgery. 2024;47(1). doi:10.1007/s00238-024-02209-x