Our eyes are among the most complex organs in the human body, capable of distinguishing around 10 million different colors and processing visual information in milliseconds. Yet, the skin surrounding them, particularly the under-eye area, is far more delicate and vulnerable to the effects of aging, fatigue, and environmental stressors. As aesthetic treatments evolve, more targeted solutions are emerging to address these concerns with precision and care.

One such innovation is PhilArt Eye, a polynucleotide-based injectable explicitly designed for the periorbital region. While it offers promising benefits for skin hydration and elasticity, like any injectable treatment, it comes with potential side effects. These can range from mild, temporary reactions to more serious complications, depending on technique, anatomy, and patient sensitivity.

In this article, we’ll explore the complete list of PhilArt Eye side effects, from the most common to the rare.

Key Takeaways

  • PhilArt Eye is a specialized injectable designed to improve the quality of periorbital skin using polynucleotides (PN), derived from salmon DNA fragments, which enhance hydration, elasticity, and promote tissue repair.
  • The treatment is injected into the subdermis or deep dermis using a 30-G needle or cannula, requiring precise techniques due to the proximity of blood vessels and nerves.
  • Common side effects include swelling, bruising, and redness, which are mild and typically resolve within a few days.
  • More serious, though rare, side effects may include persistent swelling, nodules, or even vascular compromise, but these can be minimized with proper technique and care.
  • To minimize risks, practitioners should possess a thorough understanding of anatomy, use blunt-tip cannulas, and adhere to sterile techniques during the procedure.
  • Post-treatment care involves avoiding strenuous exercise, makeup, and heat for at least 24 hours to optimize recovery.

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Understanding PhilArt Eye’s Periorbital Application

PhilArt Eye is a revolutionary injectable treatment designed specifically for the delicate periorbital area, where the skin is thinner and more sensitive. It contains polynucleotides (PN), derived from salmon DNA fragments, which promote hydration, improve skin elasticity, and accelerate tissue repair. PhilArt Eye is injected into the superficial subdermis or deep dermis using a 30-G needle or cannula, with the treatment requiring a precise technique due to the proximity to vessels and nerves in this sensitive area.

injection for under eye

Practitioners often use techniques like fanning or linear threading to ensure an even distribution of the product. Understanding the anatomy of the under-eye area is crucial to avoid complications. A careful and conservative approach is essential to minimize risks such as bruising or lumps in the treated area.

Common Side Effects Reported With PhilArt Eye

As with any injectable treatment, PhilArt Eye may lead to temporary side effects. These effects are typically mild, short-lived, and localized to the area of injection. Being aware of these expected reactions helps patients set realistic expectations and ensures proper aftercare.

  • Swelling: Mild puffiness is common, especially in the first 24–48 hours after treatment. It usually resolves within a few days.
  • Bruising: The under-eye area is highly vascular, so bruising is a possibility but typically fades within a few days.
  • Redness: Mild erythema (redness) may occur shortly after the procedure but should subside within a few hours.
  • Tenderness or Discomfort: A dull ache or mild tenderness at the injection site is typical but generally fades quickly.
  • Itching: Some patients experience mild itching as the skin heals.
  • Firmness at the Injection Point: Temporary firmness may appear due to localized product placement.
  • Pinpoint Bleeding: Small blood spots may appear at the injection points but typically subside quickly.

These side effects are typically not a cause for concern and can be easily managed with basic aftercare, such as cold compresses and avoiding strenuous activity.

Less Frequent or Serious Reactions to PhilArt Eye

While PhilArt Eye is generally well-tolerated, less common or more serious side effects can occasionally occur. Although these are rare, it’s important to monitor for them and address them promptly:

swollen eyes
  • Prolonged Swelling (Edema): In some rare cases, fluid retention may persist for several days.
  • Papules or Nodules: Small bumps may form if the product is injected too superficially or unevenly.
  • Persistent Erythema: Some patients may experience redness that lasts beyond the usual healing time.
  • Hypersensitivity Reactions: Rare allergic reactions may cause symptoms like itching, swelling, or redness.
  • Tyndall Effect: A bluish tint may appear under the skin if the product is injected too superficially.
  • Infection: Although rare, any break in the skin can lead to infection, making sterile technique essential.
  • Vascular Compromise: Accidental injection near a vessel could cause ischemia or skin necrosis, but this is extremely rare when administered by a skilled practitioner.

Providers must inform patients about these possibilities during consultation and ensure that any unusual symptoms are immediately addressed.

Minimizing Risk When Using PhilArt Eye in Practice

To reduce the risk of side effects and ensure safe, effective treatment, several precautions should be followed:

proper eyecare
  • Thorough Patient Screening: Exclude individuals with active skin infections, autoimmune conditions, or known sensitivity to polynucleotides.
  • Anatomical Knowledge: A strong understanding of orbital anatomy is vital, particularly the vasculature and fat compartments surrounding the eyes.
  • Choose the Right Tool: Using a blunt-tip cannula can reduce trauma and minimize bruising compared to sharp needles.
  • Correct Injection Depth: Ensuring the product is injected into the subdermal or deep dermal plane reduces the risk of surface-level bumps or the Tyndall effect.
  • Conservative Dosing: Always start with a minimal amount of product to avoid overcorrection, particularly during the first session.
  • Sterile Technique: Maintaining sterile conditions throughout the procedure is essential to minimize the risk of infection.
  • Post-Treatment Instructions: Advise patients to avoid heat, strenuous exercise, or makeup for at least 24 hours after the treatment to ensure optimal healing.

By adhering to these precautions, practitioners can significantly reduce risks and ensure that patients achieve the best results possible, as reflected in many Croma PhilArt reviews from satisfied patients and practitioners.

Conclusion

PhilArt Eye offers a safe and effective option for enhancing the delicate skin under the eyes. Although most side effects are mild and temporary, rare adverse events require careful monitoring. The key to minimizing risks is proper technique, understanding the anatomy, and conducting thorough patient assessments.

When PhilArt Eye is administered with care, it can offer significant improvements in periorbital skin quality, leading to enhanced patient satisfaction and natural-looking results. By adhering to best practices and providing clear post-procedure guidance, practitioners can ensure the safety and success of the treatment.

FAQs

1. How long do Philart Eye side effects last?

Most side effects like swelling and bruising resolve within 3 to 5 days. Rare reactions may take longer.

2. Can anyone get Philart Eye treatment?

Not everyone is a good candidate. Patients with skin infections, bleeding disorders, or allergies to ingredients should avoid it.

3. How many sessions are typically needed?

A treatment plan usually involves 2 to 3 sessions spaced about 3 to 4 weeks apart for best results.

Patients should avoid sun exposure, alcohol, heat, and makeup for 24 hours post-procedure. Cold compresses may help.

5. Is Philart Eye safe for dark circles?

Yes, it may help improve skin quality and reduce dark shadows, but it’s not a pigment treatment. Results vary.

6. What’s the difference between Philart Eye and tear trough fillers?

Philart Eye uses polynucleotides to regenerate tissue, while fillers add volume. They address different concerns.

7. Are the results permanent?

No, effects are temporary and may last 6 to 9 months. Maintenance sessions are usually needed for long-term benefits.

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References

Naidoo K, Birch-Machin M. Oxidative stress and ageing: the influence of environmental pollution, sunlight and diet on skin. Cosmetics. 2017;4(1):4. doi:10.3390/cosmetics4010004

Lett B. Understanding dry and wrinkled under eye skin. Eye Surgery Guide. Published March 13, 2025. https://eyesurgeryguide.org/understanding-dry-and-wrinkled-under-eye-skin/

Croma-Pharma introduces its newest injectable polynucleotide, PhilArt. Aesthetic Medicine. https://aestheticmed.co.uk/croma-pharma-introduces-its-newest-injectable