ACTEMRA®
ACTEMRA® (tocilizumab) is a prescription biologic used to treat chronic inflammatory conditions like rheumatoid arthritis and juvenile idiopathic arthritis. It works by blocking the interleukin-6 (IL-6) receptor, a key player in the inflammatory process. Available in both intravenous (IV) and subcutaneous (SC) forms, ACTEMRA® offers flexible dosing options for adults and children.
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What Is ACTEMRA®?
ACTEMRA® is a biologic therapy designed to reduce inflammation by targeting the IL-6 receptor. It’s indicated for several autoimmune conditions and is often used when other treatments haven’t worked well enough.
- Indicated for:
- Moderately to severely active Rheumatoid Arthritis (RA) in adults
- Polyarticular Juvenile Idiopathic Arthritis (PJIA) in children ≥2 years
- Systemic Juvenile Idiopathic Arthritis (SJIA) in children ≥2 years
- Initial U.S. approval: 2010
- Can be used alone or with methotrexate and other DMARDs
Why ACTEMRA® Might Be Right for Your Patients
ACTEMRA® offers an alternative for patients who haven’t responded adequately to other disease-modifying antirheumatic drugs (DMARDs). Its dual administration formats and weight-based dosing provide adaptability for a range of clinical settings.
- Effective in both adult and pediatric populations
- Monotherapy or combination use allowed
- Suitable for patients with methotrexate intolerance
- Weight-based dosing helps personalize treatment
- Available as IV infusion or SC injection
Products in the ACTEMRA® Line
ACTEMRA® comes in different formulations and strengths to meet various treatment needs. All products are single-use and preservative-free.
- IV vials (20 mg/mL):
- 80 mg / 4 mL
- 200 mg / 10 mL
- 400 mg / 20 mL
- SC Prefilled Syringe:
- 162 mg / 0.9 mL single-use syringe
Where and How ACTEMRA® Is Used
ACTEMRA® is administered either intravenously or subcutaneously depending on the patient’s condition and weight. IV is typically used in pediatric cases, while adults may use either format.
- RA IV dosage: Start at 4 mg/kg every 4 weeks, can increase to 8 mg/kg
- RA SC dosage:
- <100 kg: 162 mg every other week, increase to weekly if needed
- ≥100 kg: 162 mg every week
- PJIA IV dosage (every 4 weeks):
- <30 kg: 10 mg/kg
- ≥30 kg: 8 mg/kg
- SJIA IV dosage (every 2 weeks):
- <30 kg: 12 mg/kg
- ≥30 kg: 8 mg/kg
What’s in ACTEMRA®?
ACTEMRA® contains the active monoclonal antibody tocilizumab. The formulation does not include preservatives and should be handled using aseptic techniques.
- Active substance: Tocilizumab
- IV solution: 20 mg/mL in various vial sizes
- SC syringe: 162 mg/0.9 mL
- Form: Clear to pale yellow liquid
- No preservatives
How to Inject ACTEMRA®
ACTEMRA® should be administered exactly as instructed. IV infusions must be prepared and given by healthcare professionals, while SC injections can be performed by trained patients or caregivers.
- IV infusion:
- Dilute in 0.9% Sodium Chloride (50 or 100 mL)
- Infuse over 60 minutes
- Do not administer as a push or bolus
- SC injection:
- Inject 162 mg/0.9 mL in full
- Rotate injection sites
- Avoid scars, bruises, or irritated skin
How to Store ACTEMRA®
Proper storage is essential to maintain the safety and efficacy of ACTEMRA®. Follow the recommendations closely for each formulation.
- Store at: 2°–8°C (36°–46°F)
- Do not freeze or shake
- Protect from light
- Use diluted IV solutions within 24 hours
- Discard any unused product; vials are single-use only
What ACTEMRA® Side Effects Should You Know About?
ACTEMRA® may cause side effects ranging from mild to serious. Regular lab monitoring is recommended during treatment.
- Common side effects (≥5%):
- Upper respiratory tract infections
- Headache
- Injection site reactions
- Increased ALT
- Hypertension
- Serious risks:
- Serious infections (e.g., TB, fungal)
- GI perforation
- Liver enzyme elevation
- Neutropenia, thrombocytopenia
- Hypersensitivity reactions, including anaphylaxis
- Monitoring: ALT, AST, neutrophils, platelets, lipids
Questions We Often Hear About ACTEMRA®
Can ACTEMRA® be combined with methotrexate? Yes, ACTEMRA® can be used with or without methotrexate or other non-biologic DMARDs.
Is ACTEMRA® suitable for children? Yes, for children ≥2 years old with PJIA or SJIA, but only via IV.
Does ACTEMRA® suppress the immune system? Yes, it is an immunosuppressant and may increase infection risk.
Are vaccinations allowed during treatment? Live vaccines should be avoided. Patients should be up to date on immunizations before starting treatment.
Ready to Order ACTEMRA®?
ACTEMRA® offers targeted control for inflammatory arthritis when other therapies fall short. With flexible dosing and proven safety data, it can be a valuable tool in your practice.
Reach out to Medical Spa RX and order ACTEMRA® at wholesale prices today!
Other information
What Is ACTEMRA®?
ACTEMRA® is a biologic therapy designed to reduce inflammation by targeting the IL-6 receptor. It’s indicated for several autoimmune conditions and is often used when other treatments haven’t worked well enough.
- Indicated for:
- Moderately to severely active Rheumatoid Arthritis (RA) in adults
- Polyarticular Juvenile Idiopathic Arthritis (PJIA) in children ≥2 years
- Systemic Juvenile Idiopathic Arthritis (SJIA) in children ≥2 years
- Initial U.S. approval: 2010
- Can be used alone or with methotrexate and other DMARDs
Why ACTEMRA® Might Be Right for Your Patients
ACTEMRA® offers an alternative for patients who haven’t responded adequately to other disease-modifying antirheumatic drugs (DMARDs). Its dual administration formats and weight-based dosing provide adaptability for a range of clinical settings.
- Effective in both adult and pediatric populations
- Monotherapy or combination use allowed
- Suitable for patients with methotrexate intolerance
- Weight-based dosing helps personalize treatment
- Available as IV infusion or SC injection
Products in the ACTEMRA® Line
ACTEMRA® comes in different formulations and strengths to meet various treatment needs. All products are single-use and preservative-free.
- IV vials (20 mg/mL):
- 80 mg / 4 mL
- 200 mg / 10 mL
- 400 mg / 20 mL
- SC Prefilled Syringe:
- 162 mg / 0.9 mL single-use syringe
Where and How ACTEMRA® Is Used
ACTEMRA® is administered either intravenously or subcutaneously depending on the patient’s condition and weight. IV is typically used in pediatric cases, while adults may use either format.
- RA IV dosage: Start at 4 mg/kg every 4 weeks, can increase to 8 mg/kg
- RA SC dosage:
- <100 kg: 162 mg every other week, increase to weekly if needed
- ≥100 kg: 162 mg every week
- PJIA IV dosage (every 4 weeks):
- <30 kg: 10 mg/kg
- ≥30 kg: 8 mg/kg
- SJIA IV dosage (every 2 weeks):
- <30 kg: 12 mg/kg
- ≥30 kg: 8 mg/kg
What’s in ACTEMRA®?
ACTEMRA® contains the active monoclonal antibody tocilizumab. The formulation does not include preservatives and should be handled using aseptic techniques.
- Active substance: Tocilizumab
- IV solution: 20 mg/mL in various vial sizes
- SC syringe: 162 mg/0.9 mL
- Form: Clear to pale yellow liquid
- No preservatives
How to Inject ACTEMRA®
ACTEMRA® should be administered exactly as instructed. IV infusions must be prepared and given by healthcare professionals, while SC injections can be performed by trained patients or caregivers.
- IV infusion:
- Dilute in 0.9% Sodium Chloride (50 or 100 mL)
- Infuse over 60 minutes
- Do not administer as a push or bolus
- SC injection:
- Inject 162 mg/0.9 mL in full
- Rotate injection sites
- Avoid scars, bruises, or irritated skin
How to Store ACTEMRA®
Proper storage is essential to maintain the safety and efficacy of ACTEMRA®. Follow the recommendations closely for each formulation.
- Store at: 2°–8°C (36°–46°F)
- Do not freeze or shake
- Protect from light
- Use diluted IV solutions within 24 hours
- Discard any unused product; vials are single-use only
What ACTEMRA® Side Effects Should You Know About?
ACTEMRA® may cause side effects ranging from mild to serious. Regular lab monitoring is recommended during treatment.
- Common side effects (≥5%):
- Upper respiratory tract infections
- Headache
- Injection site reactions
- Increased ALT
- Hypertension
- Serious risks:
- Serious infections (e.g., TB, fungal)
- GI perforation
- Liver enzyme elevation
- Neutropenia, thrombocytopenia
- Hypersensitivity reactions, including anaphylaxis
- Monitoring: ALT, AST, neutrophils, platelets, lipids
Questions We Often Hear About ACTEMRA®
Can ACTEMRA® be combined with methotrexate? Yes, ACTEMRA® can be used with or without methotrexate or other non-biologic DMARDs.
Is ACTEMRA® suitable for children? Yes, for children ≥2 years old with PJIA or SJIA, but only via IV.
Does ACTEMRA® suppress the immune system? Yes, it is an immunosuppressant and may increase infection risk.
Are vaccinations allowed during treatment? Live vaccines should be avoided. Patients should be up to date on immunizations before starting treatment.
Ready to Order ACTEMRA®?
ACTEMRA® offers targeted control for inflammatory arthritis when other therapies fall short. With flexible dosing and proven safety data, it can be a valuable tool in your practice.
Reach out to Medical Spa RX and order ACTEMRA® at wholesale prices today!