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Product Description

LATISSE® Product Overview

LATISSE®  is a prescription treatment developed for hypotrichosis of the eyelashes, a condition characterized by inadequate lash growth. LATISSE® works as a prostaglandin analog, promoting longer, thicker, and darker eyelashes. Administered via a nightly application on the upper eyelid margin, it is generally well-tolerated, providing visible results within 8-16 weeks.

Key Features:

• Active Ingredient: Bimatoprost 0.3 mg/mL
• Application: Once nightly on the upper eyelid margin
• Primary Action: Increases lash growth in terms of length, thickness, and darkness
• Pack Size: 5ml in a 5ml bottle with 140 applicators

LATISSE® Indications for Use

LATISSE® is indicated for eyelash hypotrichosis treatment, specifically enhancing the length, thickness, and pigmentation of lashes. Patients often observe noticeable improvements by the end of a 16-week treatment cycle.

Primary Indications:

• Eyelash Growth: Increases the length, density, and darkness of eyelashes for those experiencing thin or sparse lash growth.

LATISSE® Dosage Information

LATISSE® is intended for nightly application using sterile applicators included in the package. Application on the lower lid is not advised due to potential unintended hair growth on nearby areas.

Application Protocol:

• Dosage: Apply one drop of LATISSE® on the sterile applicator, applying it along the upper eyelid margin at the base of the lashes.
• Frequency: Once nightly; additional applications do not enhance results.
• Precautions: Remove makeup and contact lenses before application. Blot any excess product outside the lash line with a tissue.

Expected Outcomes:

• Onset of Results: Visible growth improvement typically begins after 8 weeks, with full effects around 16 weeks.
• Post-Treatment Changes: If treatment is discontinued, lashes gradually return to their baseline appearance over several weeks to months.

LATISSE® Side Effects and Precautions

LATISSE® has a favorable safety profile but may lead to mild side effects in some patients. Notable precautions are advised for those using intraocular pressure-lowering agents, as LATISSE® may reduce their effectiveness.

Common Side Effects:

• Eye Itching or Redness: Reported in about 4% of patients.
• Skin Pigmentation: Darkening of the upper eyelid skin, which may be reversible upon discontinuation.
• Eye Dryness or Irritation: Occasional reports of ocular discomfort or dryness.

Warnings and Precautions:

• Intraocular Pressure (IOP) Concerns: Patients using intraocular pressure-lowering agents should consult with their physician before use, as LATISSE® may interfere with desired IOP reduction.
• Iris Pigmentation: Increased pigmentation of the iris (brown coloring) may occur, which is typically irreversible.
• Periorbital Hair Growth: LATISSE® should be applied only to the upper eyelid margin, as excess application may result in hair growth in unintended areas.
• Handling Precautions: Use a new applicator for each eyelid to avoid contamination, which can lead to infections.

LATISSE® Clinical Studies or Real-World Outcomes

Clinical trials for LATISSE® demonstrate significant efficacy, with patients observing longer, thicker, and darker lashes by week 16.

Study Findings:

• Eyelash Prominence: 78% of LATISSE® users reported a one-grade increase in overall lash prominence by week 16, compared to 18% of the control group.
• Measurement Outcomes: On average, eyelash length increased by 25%, thickness by 106%, and darkness by 18%.
• Patient Satisfaction: High satisfaction due to improvements in lash appearance, with minimal side effects in the majority of patients.

Clinical Observations:

• Efficacy in Adolescents: LATISSE® has also shown safe use in teenagers with hypotrichosis, providing similar efficacy to adults.
• Gradual Effect Reversal: After the 16-week application cycle, effects diminish over time if treatment is stopped, reverting to the baseline lash appearance.

LATISSE®  Composition and Active Ingredients

LATISSE® contains bimatoprost 0.3 mg/mL as its active ingredient, supported by other compounds that stabilize the solution for safe, effective use on delicate eye tissues.

Key Ingredients:

• Bimatoprost: A prostaglandin analog that extends the anagen (growth) phase of eyelash hair cycles.
• Benzalkonium Chloride: A preservative; contact lenses should be removed before application and reinserted 15 minutes later to prevent lens discoloration.

LATISSE® Drug Interactions

While LATISSE® has minimal systemic absorption, precautions are necessary for patients using medications that may interact with prostaglandin analogs.

Important Considerations:

• Concurrent Use with Prostaglandin Analogs: Patients using other prostaglandin analogs for IOP management should consult their physician, as LATISSE® may reduce the effectiveness of these medications.
• Intraocular Anti-Inflammatories: LATISSE® should be used cautiously in patients with active intraocular inflammation due to potential exacerbation.