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    brand:

    BOTOX®

    manufacturer:

    Allergan

    active substances:

    BOTULINUM TOXIN TYPE A

    strength:

    100u

    pack size:

    1 x 100u Vial

    INFORMATION

    BOTOX® 100u Indications for Use

    BOTOX® is used for a wide range of therapeutic and cosmetic applications. Its primary action is to block the release of acetylcholine, preventing muscle contractions in the treated area. This effect is beneficial for conditions such as:

    • Chronic migraine (prevents headaches in patients with a history of migraines)
    • Cervical dystonia (treats abnormal head position and neck pain)
    • Blepharospasm (treats involuntary blinking)
    • Strabismus (corrects eye misalignment)
    • Overactive bladder and urinary incontinence due to neurological disorders
    • Facial wrinkles (glabellar lines, crow’s feet, and forehead lines)

    BOTOX® 100u Dosage Information

    BOTOX® dosage varies depending on the condition being treated. The following are common doses for cosmetic and medical applications:

    • Glabellar lines: 20 Units, injected into five sites (4 Units per site)
    • Crow’s feet: 24 Units, injected into six sites (4 Units per site)
    • Forehead lines: 20 Units, typically combined with 20 Units for glabellar lines, for a total of 40 Units
    • Maximum dose: No more than 400 Units within three months for combined treatments

    Each vial contains either 50 Units or 100 Units of vacuum-dried powder. The powder requires reconstitution with saline before injection, and each injection should be administered with precision to avoid complications.

    BOTOX® 100u Side Effects and Precautions

    While BOTOX® is generally well-tolerated, certain side effects may occur, particularly at the injection site:

    • Common side effects:
      • Headache: Occurs in 9% of patients treated for forehead lines
      • Eyelid ptosis: Seen in 2% of patients receiving BOTOX® for cosmetic purposes
      • Injection site reactions: Pain, redness, and swelling at the injection site
    • Severe side effects (less common):
      • Dysphagia, respiratory distress, and distant spread of toxin effects
      • Possible in patients with pre-existing neuromuscular disorders, such as myasthenia gravis or amyotrophic lateral sclerosis
      • Symptoms such as generalized muscle weakness and dysphonia may occur

    Precautionary measures include:

    • Avoid using in patients with hypersensitivity to botulinum toxin or infections at the injection site
    • Ensure proper administration to avoid vascular occlusion or injection into blood vessels

    BOTOX® 100u Clinical Studies and Real-World Outcomes

    Multiple clinical studies demonstrate the efficacy of BOTOX® for both therapeutic and cosmetic uses. The following results have been recorded:

    • Forehead lines: Significant reduction in wrinkles within 7 days, with results lasting up to 4 months
    • Glabellar lines: Improvement in moderate to severe wrinkles seen in 80% of patients after treatment
    • Crow’s feet: Visible improvement in 75% of patients at Day 30, with effects lasting up to 3 months

    For therapeutic conditions:

    • Chronic migraine: Reduces the number of headache days per month by 50% in most patients after two treatments
    • Cervical dystonia: Reduces abnormal head posture and neck pain within 4 to 6 weeks after injection
    • Overactive bladder: Significant reduction in incontinence episodes, with improvement lasting 6 to 8 months

    BOTOX® 100u Drug Interactions

    Certain medications may interact with BOTOX®, increasing the risk of adverse effects. These include:

    • Aminoglycosides: Enhance the neuromuscular blocking effect, leading to increased muscle weakness
    • Anticholinergic drugs: Increase systemic effects of BOTOX®, such as dry mouth and blurred vision
    • Muscle relaxants: May cause enhanced muscle weakness if administered concurrently

    It is recommended that patients inform their healthcare provider of all medications they are taking to avoid these interactions.

    Special Populations

    BOTOX® has specific usage recommendations for different patient populations:

    • Pregnancy: There is insufficient data on the safety of BOTOX® during pregnancy. Animal studies have shown potential risks, and the drug should only be used if the potential benefit justifies the risk.
    • Breastfeeding: Caution is advised, as it is unknown whether the drug is excreted in human milk.
    • Pediatric use: Approved for certain conditions such as spasticity in children with cerebral palsy, but not recommended for other uses in children under 18 years of age.

    BOTOX® 100u Administration Guidelines

    The proper administration of BOTOX® is critical to ensure safety and efficacy:

    • Injection sites: Should be chosen carefully depending on the condition being treated
      • For facial wrinkles: Inject into specific muscles such as the corrugator and procerus muscles for glabellar lines
      • For therapeutic use: Administer into affected muscles or bladder wall for overactive bladder
    • Needle size: Use a fine gauge needle to minimize discomfort and reduce the risk of complications
    • Storage: Reconstituted vials must be used within 24 hours and stored at 2°C to 8°C

    BOTOX® 100u Precautions After Treatment

    Patients are advised to take specific precautions after BOTOX® treatment to avoid complications:

    • Avoid strenuous physical activities for 24 hours after injection
    • Refrain from massaging or rubbing the treated area to prevent toxin migration
    • Sun exposure, extreme heat, and UV radiation should be avoided for at least 48 hours

    Most patients experience a return to normal activities shortly after the procedure, with minimal downtime required.

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