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Restylane Silk vs Juvederm: Target Areas, Comparison, and Review

Restylane Silk vs Juvederm: Target Areas, Comparison, and Review

11 July

Throughout the years, researchers have found a way to replenish the hyaluronic acid in the body without extracting it from animals. As a result of Streptococci biofermentation, dermal fillers like Juvederm and Restylane can integrate with the soft tissues safely, with low risk of rejection and complications.

Since the lips are vulnerable structures on the face, a more in-depth review on the hyaluronic acid’s composition may be useful. Many doctors with experience have noted that Juvederm is suitable for lips augmentation, whereas Restylane Silk is soft enough for diminishing the fine lines. These two products may use the same ingredient but the subtle differences in its configuration creates a different outcome of the treatment.

Target Areas: Juvederm vs Restylane Silk for Lips

Juvederm Volbella is made using Vycross Technology. This process creates a strong bond among the hyaluronic acid chains, creating a sturdy network that resists enzymatic degradation for a longer time. It also forms a viscoelastic implant that can attach and conform to the neighboring contours and soft tissues. The strong covalent bonds allow resistance from collapsing against dynamic movements or pressure.

Juvederm’s particles are larger in comparison to Restylane. This characteristic is optimal for lip augmentation or plumping up the lips. The large particles can increase the volume of the lips while providing luscious, soft texture. Therefore, patients who wish to have more definition in their lip volume can opt for Juvederm, achieving their desired pout.

Restylane Silk is made using Non-Animal Stabilized Hyaluronic Acid (NASHA) Technology, which forms stabilized HA and increases the longevity, malleability, and elasticity of the gel.

Restylane Silk is a dermal filler that is specifically designed for the lips. Using smaller particles of 20mg/ml hyaluronic acid, an injection to the lips, vermilion border and perioral area can correct the wrinkles and folds formed due to smoking and pouting. As a result, patients can enjoy a natural-looking lip rejuvenation with Restylane Silk.

Both fillers are usually used for lip rejuvenation; however, some doctors prefer Restylane Silk due to the gel texture.


Clinical trials have been conducted to discover the efficacy of Restylane Silk and Juvederm Volbella for lips. In a trial with Restylane Silk, 76% of 221 subjects reported lip improvement after six months.

Juvederm Volbella, in a similar study, found that 93% of subjects were satisfied with an overall improvement in lip fullness and perioral lines after three months. In addition, more than half of these subjects were still satisfied with the results after a year post-treatment.

Another study comparing Restylane-L and Juvederm Volbella found that Volbella induced less swelling.


Restylane Silk can sustain the smooth, glossy look of the lips for six to nine months. The implant may take a few days to take effect, with 98% of visible improvement after 14 days. These results are sustained for six to nine months.

Juvederm’s stronger bond and elasticity can maintain plump lips up to a year. The increased volume can be immediately seen after the initial treatment. To achieve optimal result, administer a touch-up treatment one month after the initial session.

Disclaimer: The contents of this article are for informational purposes only and must not be considered as medical advice. We, do not agree, endorse, or approve opinions expressed by authors of our medical community. Articles are not reviewed for accuracy by You should always consult your doctor when seeking medical advice.

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