Did you know that in 2019, approximately 528 million people worldwide were living with osteoarthritis? That’s a staggering increase of 113% since 1990, making it a significant public health concern. Intra-articular knee injections have become a standard treatment, with a majority of physicians utilizing steroid therapy for pain management.

Euflexxa, a viscosupplement injection containing 1% sodium hyaluronate, offers an alternative for those who find insufficient relief from standard treatments like acetaminophen or physical therapy. It acts as a lubricant and shock absorber for the joints, aiming to alleviate knee pain caused by osteoarthritis.

In this article, we will explore the potential side effects of Euflexxa injections and provide guidance on minimizing risks while maximizing therapeutic benefits.

Key Takeaways

  • Euflexxa is a viscosupplement used for knee osteoarthritis.
  • Common side effects include localized pain, swelling, and stiffness.
  • Rare but serious side effects may include allergic reactions, infection, and blood clots.
  • Proper injection techniques and post-treatment care can help minimize the risk of side effects.

Common Side Effects of Euflexxa

  • Localized Pain: Most patients ask questions like “Do Euflexxa injections hurt?” or “Will it cause mobility issues?” and doctors say there is discomfort. This can include warmth, redness, and even bruising or puffiness around where the needle went. Despite these relatively common reactions, they are generally short-lived and should lessen over time.
  • Swelling: Swelling is a common side effect after getting Euflexxa injections. This can show up as puffiness or feeling complete around the knee area where you got the shot. It’s part of how your body reacts to the treatment, aiming to ease joint pain from osteoarthritis.
  • Stiffness: People might find it hard to bend their knee or use the joint like they normally would. The good news is that this stiffness usually does not last long.

Rare but Serious Side Effects of Euflexxa

Blood stream.
  • Allergic Reactions: Allergic reactions to Euflexxa can be severe. Some people might experience hypersensitivity reactions, such as anaphylaxis or anaphylactoid reactions. This means their body reacts strongly against the injection.
  • Infection: Prompt recognition and treatment are vital. Patients must report any signs of infection immediately to their healthcare provider. Proper sterility during the injection process minimizes this risk.
  • Blood Clots: Euflexxa injections are primarily safe but carry risks like all treatments, including blood clots. People getting these shots should watch for signs like swelling and redness that could point to a clot.

Managing Euflexxa Side Effects

Knee pain.

Euflexxa side effects often involve discomfort at the injection site, among other reactions. Knowing how to address these can improve patient comfort.

  • Apply ice packs to the injected area to reduce swelling and pain. This cold therapy can ease localized pain, redness, and puffiness.
  • Encourage gentle movement of the knee following the injection. This can help alleviate stiffness and improve joint function.
  • Advise patients to rest if they feel severe pain or swelling but to avoid prolonged inactivity that might worsen stiffness.
  • Over-the-counter pain relievers may be recommended for managing pain.
  • Keep the injection site clean to prevent infection, a severe but rare side effect.
  • Monitor for signs of allergic reactions such as itching of the skin or difficulty swallowing, and guide patients on when to seek immediate medical help.
  • Educate patients about potential gastrointestinal effects like nausea or diarrhea and suggest eating bland foods or staying hydrated.

  • Shirt sleeves should be loose-fitting to avoid putting pressure on the injection site, reducing the risk of irritation or blood clots.
  • Teach proper care after treatment, like avoiding high-impact activities for 48 hours post-injection to minimize joint stress.
  • Stay informed about each patient’s medical history before Euflexxa administration, particularly allergies or reactions to injections, which could inform pre-treatment precautions.

These steps can help manage common side effects of Euflexxa injections and enhance patient care during treatment for knee osteoarthritis. Patients and healthcare professionals must stay alert to hyaluronic acid injections’ rare but significant risks.

Minimizing the Risk of Euflexxa Side Effects

Knee pain.
  • Proper Injection Techniques: Using the correct technique for Euflexxa injections is critical. Ensure the skin is clean, and choose a different site each time to avoid irritation. Inject slowly, directly into the knee joint space.
  • Post-Treatment Care and Precautions: This allows the injected area to heal correctly. Also, if any signs of allergic reaction like swelling or difficulty breathing occur, seek medical help immediately.

Also essential is reporting severe side effects, such as infection signs or blood clots, immediately for professional evaluation and treatment guidance. This proactive approach helps manage potential risks effectively while ensuring a smooth recovery process.


Euflexxa’s side effects range from mild to severe. Knowing these can help avoid more significant issues. Always follow doctors’ instructions and report bad reactions quickly. Proper care makes treatment safer. This way, patients get relief with fewer worries.


1. What are Euflexxa’s side effects?

Euflexxa side effects can vary, but they may include reactions at the injection site, swelling in the knee, or headaches.

2. How common are these side effects?

The frequency of these side effects can differ from person to person. Some people experience them more often than others.

3. Is there a way to avoid Euflexxa’s side effects?

Certain precautions can help reduce the likelihood of experiencing Euflexxa’s side effects. These could involve following your doctor’s instructions closely and reporting discomfort immediately.

4. What should I do if I experience these side effects?

If you encounter any of Euflexxa’s side effects, it is crucial to contact your healthcare provider immediately for advice on the next steps.

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World Health Organization: WHO, World Health Organization: WHO. Osteoarthritis. Published July 14, 2023. https://www.who.int/news-room/fact-sheets/detail/osteoarthritis

Drugs.com. (n.d.). Euflexxa side effects. Drugs.com. Retrieved July 9, 2024, from https://www.drugs.com/sfx/euflexxa-side-effects.html

Drugs.com. (n.d.). Euflexxa injection. Drugs.com. Retrieved July 9, 2024, from https://www.drugs.com/mtm/euflexxa-injection.html