Woman getting facial fillers.

Innovative treatments continually reshape the landscape of aesthetic medicine, with injectable fillers leading the charge. Over the years, experts and aesthetic specialists have observed how soft tissue filler treatments keep increasing, highlighting the escalating demand for these minimally invasive procedures.

Restylane and Juvederm have established themselves as leaders among cosmetic fillers. Restylane is known for its granular texture, ideal for sculpting and adding volume. Meanwhile, Juvederm’s smoother gel is adept at filling fine lines and wrinkles. Both use hyaluronic acid to plump the skin, yet their distinct properties cater to different aesthetic desires.

In this article, we will compare Restylane and Juvederm, examining their composition, application, and the results one can expect to provide a clear perspective on how they stand apart in cosmetic enhancement.

Key Takeaways

  • Restylane and Juvederm are two leading brands of hyaluronic acid-based dermal fillers widely used in aesthetic medicine.
  • Both fillers have unique formulations, indications, longevity, injection techniques, patient satisfaction rates, and safety profiles.
  • Understanding the differences between Restylane and Juvederm is crucial for medical professionals to make informed decisions when selecting the most suitable filler for their patient’s aesthetic goals and preferences.

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Introduction to Restylane and Juvederm 

Woman getting facial fillers.

Restylane is a popular choice among medical professionals for wrinkle treatment. It uses hyaluronic acid to smooth out lines and bring back volume to the face. This filler has stabilized hyaluronic acid gel particles.

Juvederm’s secret lies in its use of hyaluronic acid, a naturally occurring substance in the skin. The product stands out due to its malleable gel form, which smoothly integrates with facial tissues to restore volume and rejuvenate appearances.

Formulations and Composition

Restylane uses hyaluronic acid to smooth out wrinkles and restore facial volume. This ingredient acts like a sponge in the skin, holding onto water for a plumper look. The unique thing about Restylane’s formula is its specific particle size and how these particles are crosslinked.

Moving from Restylane to Juvederm, the focus shifts to another popular choice for those aiming to combat signs of aging through dermal fillers. Juvederm’s formula also banks on hyaluronic acid, a key molecule known for its skin-plumping and anti-aging effects.

Cross-linking AgentButanediol Diglycidyl Ether (BDDE)BDDE
Concentration of Hyaluronic Acid20 mg/mL24 mg/mL
Particle SizeVarying sizes for different product linesSmaller, more uniform sizes leading to smoother injection
Lidocaine InclusionAvailable in select products for pain reductionCommonly included to enhance patient comfort
Range of ViscosityWide range to suit various treatment areasGenerally lower, promoting ease of injection

Indications and Approved Uses

Woman getting facial fillers.

Restylane and Juvederm are used to smooth wrinkles and add volume to the face. Doctors choose them for different face parts, including Restylane for tear troughs. Restylane received FDA approval in 2003, making it a trusted choice for many seeking facial rejuvenation. 

Restylane and Juvederm can stretch beyond these confines into more creative uses. Medical professionals use these fillers off-label for lip enhancement, hand rejuvenation, and even non-surgical nose jobs.

Longevity and Durability

Restylane treatments offer lasting results for about ten months. The specific product chosen and personal factors play a significant role in this duration. Some people see their results stay for up to 12 months or more.

Switching focus from Restylane to Juvederm, we examine the duration of results for this popular filler. Juvederm is renowned for its long-lasting effects in facial rejuvenation and wrinkle reduction.

Crosslinking and particle size are critical to the longevity of Restylane and Juvederm. Crosslinking helps the filler stay stable in the body for a longer time. The more crosslinks, the slower the body breaks down the filler.

Injection Techniques and Best Practices

Woman getting facial fillers.

Proper injection techniques are critical to getting the best results from Restylane. Since Restylane has a granular and cohesive texture, so injecting it smoothly into the skin requires skill.

Juvederm fills out lines and wrinkles using a smooth texture that sets it apart from other fillers—like Restylane. For best results, experts often use injection techniques such as serial puncture and tunneling.

Injection DepthVaries by product line, generally mid-to-deep dermisTypically injected into the mid-to-deep dermis, depending on the specific product
VolumeGranular texture allows for precise volume restoration, especially in deep linesSmooth consistency is ideal for subtle volume enhancement and contouring
Potential Adverse EventsIncludes swelling, bruising, and nodules. Cohesiveness may contribute to specific injection site reactions.Common side effects include redness, bruising, and, less frequently, granulomas. Smooth texture influences the type of adverse events.

Patient Satisfaction and Safety Profiles

Patients often choose Restylane for its effective wrinkle reduction and facial volume restoration. Studies show that users are generally happy with their outcomes. This satisfaction comes from the filler’s ability to smooth out lines and bring back youthful fullness to the face.

Patients highly praise Juvederm for smoothing wrinkles and restoring facial volume. Studies show that 90.4% of people who received Juvederm Ultra Plus were happy with the results.

Characteristics of the Juvederm and Restylane

Restylane Kysse and JUVÉDERM Ultra aim for natural-looking results, each blending into the surrounding tissues. Restylane offers a slightly more granular texture that bonds well with tissue, giving a soft and natural fullness, especially in lip filler applications.

On the other hand, JUVÉDERM is known for its smooth finish that integrates quickly into the tissue for an immediate effect of volume restoration and wrinkle reduction. This difference affects how each product feels to the touch post-injection and impacts the overall satisfaction depending on individual needs.

Comparative Efficacy and Versatility

Juvederm and Restylane both work to make skin look younger. They fill wrinkles and add volume to lips with excellent results. But they work a bit differently for each person’s face. Juvederm is often the go-to for deep lines and enhancing lips because it’s smooth and works well in these areas. Because of its unique texture, Restylane can be better for fine lines and delicate areas like under the eyes.


Restylane and Juvederm are highly effective hyaluronic acid-based dermal fillers with distinct characteristics and advantages. By considering their comparative efficacy and versatility, medical experts can tailor treatments to meet individual aesthetic goals and preferences, ultimately enhancing patient satisfaction and outcomes.


1. What’s the main difference between Restylane and Juvederm?

Restylane is great for fine lines, while Juvederm works well for deeper wrinkles.

2. How long do the effects of Restylane last compared to Juvederm?

Restylane lasts about 6-12 months, but Juvederm can last up to a year or more.

3. Can I use Restylane and Juvederm together in one treatment session?

Yes, some people get both fillers in different areas during one visit to match their needs.

4. Are there any side effects with these fillers?

Both fillers might cause mild swelling or bruising at the injection site, but it usually goes away quickly.

5. Which filler is better for plumping lips, Restylane or Juvederm?

Juvederm is often chosen to give lips a fuller look because of its smooth consistency.


Claudette GJCA de Vries & Robert E Geertsma (2013) Clinical data on
injectable tissue fillers: a review, Expert Review of Medical Devices, 10:6, 835-853, DOI:

Brandt FS, Cazzaniga A. Hyaluronic acid gel fillers in managing facial aging. Clin Interv Aging. 2008;3(1):153-9. doi: 10.2147/cia.s2135. PMID: 18488885; PMCID: PMC2544360.

Healthline. (n.d.). Juvederm vs. Restylane. Retrieved from https://www.healthline.com/health/juvederm-vs-restylane