Woman getting injection.

The quest for youthful skin has led to the rise of Restylane injections, a popular choice for diminishing facial wrinkles. In a pivotal study, subjects treated with Restylane reported significantly improving lip fullness and perioral rhytids. 

Restylane, a non-animal sourced hyaluronic acid dermal filler, has been a trusted name in aesthetics since 1996. The brand’s commitment to safety and efficacy is reflected in over 65 million treatments worldwide, making it a go-to solution for natural-looking rejuvenation.

This article will explore the nuances of Restylane injections, from the procedure to their comprehensive benefits.

Key Takeaways

  • Restylane injections are a popular cosmetic procedure that utilizes a hyaluronic acid-based filler to enhance facial features, improve skin texture, and address signs of aging. 
  • The procedure is known for its safety and effectiveness in providing natural-looking results. 
  • Understanding the science behind Restylane, the injection techniques, and the clinical applications can help medical professionals confidently offer this treatment to their patients.

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The Science Behind Restylane Injections

Hyaluronic acid-based formulations, like Restylane, contain a gel packed with hyaluronic acid and use cross-linking technology. This technology makes the filler last longer under the skin.

Restylane injections work by adding hyaluronic acid to the skin. This acid attracts water, which helps make the skin look fuller and smoother. The process fills in wrinkles and adds volume to areas like the lips or cheeks.

Since Restylane is a gel made from partly cross-linked hyaluronic acid, it stays in place longer than natural hyaluronic acid. It is a good choice for fixing moderate to severe facial wrinkles and folds.

Procedure and Injection Techniques

Restylane injections use special techniques to fill wrinkles and add face volume. Medical professionals should know how to do these injections safely and effectively.

  • Serial puncture involves several small injections along a wrinkle or fold, depositing tiny amounts of filler with each poke. This technique is helpful for shallow lines or small areas needing enhancement.
  • Threading, also known as linear threading, pulls the needle through a wrinkle while slowly pushing the filler material out. It’s like drawing a line under the skin to plump it up where it’s needed most.
  • Fanning uses multiple injection points from one entry point, spreading like a fan. The filler is laid down in branches from the main line, which is excellent for larger surface areas.
  • Crosshatching creates a lattice pattern under the skin by injecting parallel lines and then crossing over them with more lines. This method provides a strong foundation for lifting and smoothing more prominent folds or recessed areas.

Treatment areas

Moving from discussing injection techniques, it’s crucial to explore the various treatment areas where Restylane truly shines. This filler plays a vital role in facial rejuvenation and contouring by targeting specific areas that show signs of aging or need enhancement.

  • Under Eyes: This area often shows signs of aging, with dark circles and hollows forming. Restylane can reduce these shadows, giving a more rested and youthful appearance.
  • Cheeks: With age, cheeks may lose volume and sag. Injecting Restylane here plumps up the area, lifting the face for a fresher look.
  • Lips: This filler works wonders for those desiring fuller lips or smoothing wrinkles around the mouth. It adds volume and defines the lip shape while tackling fine lines.
  • Marionette Lines: These lines run from the corners of the mouth down towards the chin, creating a downturned expression. Filling them in softens expressions significantly.
  • Hands: Restylane is not just for faces; It can also rejuvenate hands by restoring lost volume and making veins and tendons less noticeable.

Patient Selection Criteria

Woman getting facial injection.

Selecting suitable patients for these treatments is crucial to comparingproducts like Restylane Kysse before and after results. It’s all about ensuring safety and achieving the best results. Here’s a close look at the criteria:

  • Age and skin condition matter. Ideal candidates are usually over 21 and show signs of aging or have concerns about their facial features.
  • Health status is crucial. Patients should be physically healthy, without active skin infections or conditions that could affect healing.
  • Realistic expectations are a must. People considering Restylane must understand what the treatment can and cannot do.
  • Understanding the risks involved is essential. Everyone getting treated should know the potential side effects and agree to follow post-treatment care instructions.
  • Prior cosmetic treatments should be considered. A patient’s history with other aesthetic procedures might affect filler choice and technique.

Clinical Applications and Benefits of Restylane

Facial rejuvenation with Restylane brings back the skin’s youthfulness by adding volume and reducing wrinkles. This treatment uses hyaluronic acid to make the skin hold water better, making it look fresh and full.

Lip enhancement with Restylane fills the lips, making them fuller and smoother. Doctors use a special gel called hyaluronic acid, which is safe because it’s like what we already have in our skin. They carefully apply this gel to both the upper and lower lips using tools like ultrafine needles. This method helps create an excellent shape and eliminates wrinkles around the mouth.

Skin hydration is vital to keeping skin looking young and healthy. Restylane injections, packed with hyaluronic acid, are significant at this. Hyaluronic acid holds onto water, helping the skin stay moist and full.


Restylane injections, with their hyaluronic acid-based formulation and versatile applications, offer medical professionals a valuable tool for facial rejuvenation, lip enhancement, and skin hydration. By understanding the science behind Restylane, mastering the injection techniques, and recognizing its clinical benefits, medical experts can provide safe and effective treatments to meet the diverse needs of their patients.

With proper patient selection and skillful administration, Restylane injections can help individuals achieve natural-looking results and boost their confidence in their appearance.


1. What is a Restylane injection?

A Restylane injection is a filler that doctors use to smooth wrinkles and give your face a fuller look.

2. Does getting a Restylane injection hurt?

You might feel a quick pinch, but it’s usually not too bad.

3. How long does it take to see results from Restylane injections?

You’ll likely see the changes right away after the treatment.

4. Are there any side effects of Restylane injections?

Some people might get swelling, redness, or bruising where they got the shot.

5. How long do the effects of a Restylane injection last?

The smoother skin can last for about 6 to 18 months, depending on what kind you get.


U.S. Food and Drug Administration. (n.d.). Summary of Safety and Effectiveness Data (SSED): JUVÉDERM VOLUMA XC. Retrieved from https://www.accessdata.fda.gov/cdrh_docs/pdf14/P140029S021B.pdf

Gold M. H. (2007). Use of hyaluronic acid fillers for the treatment of the aging face. Clinical interventions in aging, 2(3), 369–376. https://doi.org/10.2147/cia.s1244

Guo, J., Fang, W., & Wang, F. (2023). Injectable fillers: current status, physicochemical properties, function mechanism, and perspectives. RSC advances, 13(34), 23841–23858. https://doi.org/10.1039/d3ra04321e