Woman with glowing skin.

Dermal fillers have revolutionized cosmetic medicine, offering non-surgical solutions for facial enhancement. According to an article by the American Society of Plastic Surgeons, over 2.7 million dermal filler procedures were performed in the United States in 2019. These injectables provide a quick and effective way to restore volume, smooth wrinkles, and achieve a youthful appearance.

Restylane and Radiesse are two popular choices, each with its unique properties. Restylane, primarily composed of hyaluronic acid, excels at plumping lips and filling fine lines. On the other hand, Radiesse, containing calcium hydroxylapatite microspheres, offers longer-lasting results and is often used for deeper wrinkles and facial contouring.

In this article, we will delve into the specifics of these fillers, compare their benefits, and guide you toward the best choice for your rejuvenation journey. 

Key Takeaways

  • Restylane and Radiesse are popular dermal fillers used for facial rejuvenation.
  • Restylane is a hyaluronic acid-based filler, while Radiesse is a calcium hydroxylapatite-based filler.
  • Both fillers have different indications and treatment areas, offering versatility in addressing various aesthetic concerns.
  • The injection techniques and treatment processes for Restylane and Radiesse may vary, potentially affecting patient experience.
  • When choosing between the two fillers, longevity, cost-effectiveness, and patient satisfaction are important factors.

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Radiesse: Comparing Dermal Fillers for Facial Rejuvenation

Woman with glowing skin.

Restylane and Radiesse are popular choices for facial rejuvenation but come from different backgrounds. Restylane is made from hyaluronic acid, which helps add volume and smooth out lines by attracting water to the skin.

On the other hand, Radiesse uses calcium hydroxylapatite particles to provide a scaffold that boosts collagen production for longer-lasting results. Each filler has strengths—Restylane works well for fine lines and delicate areas because it’s softer. At the same time, Radiesse is better suited for deeper wrinkles and adding volume due to its thicker consistency.

Introduction to Restylane and Radiesse

Deciding between Restylane and Radiesse for facial rejuvenation can be challenging. Each filler has unique benefits, like Restylane’s, which is great for fine lines due to its thinner consistency.

Dermal fillers are unique treatments that add volume to the face and reduce signs of aging. They fill in wrinkles and give more fullness to areas that have lost shape or volume over time.

With ingredients like hyaluronic acid in Restylane and calcium hydroxylapatite in Radiesse, these injectables offer different ways to refresh the skin.

Picking a suitable filler is critical for good results in facial rejuvenation. Each kind of injectable filler has its strengths. For example, Radiesse works well as a volumizer and helps make more collagen.

Formulation and Composition

Restylane uses hyaluronic acid, while Radiesse uses calcium hydroxylapatite. This choice matters a lot for your treatment’s success. Keep reading to find out why.

Hyaluronic acid, Restylane’s star ingredient, is a powerful magnet for moisture. It helps skin look plump and hydrated. This filler works wonders by smoothing wrinkles and adding volume to facial areas without surgery. Different fillers are available in the Restylane family, but their safety and efficacy allow doctors to use specific formulations like Restylane Contour for lips because of their physical qualities.

Radiesse stands out as a dermal filler because of its unique makeup. It uses calcium hydroxylapatite, a mineral-like substance found in human bones. This gives Radiesse a thicker quality compared to other fillers.

Restylane and Radiesse are made of different materials. Restylane contains hyaluronic acid, which helps your skin make more collagen for a gentle boost. Radiesse uses calcium hydroxylapatite.

Indications and Treatment Areas

Woman getting filler treatment.

Restylane works well for smoothing out wrinkles and adding volume to the face. Radiesse, on the other hand, is excellent for deeper lines and helping areas of the face that have lost volume.

Doctors use Restylane to fix wrinkles, skin folds, and volume loss in the face. This filler works best for areas that show signs of aging. One popular spot is around the mouth, where lines often appear.

Radiesse excels at smoothing moderate to severe facial wrinkles and folds. Its strength lies in treating nasolabial folds, the lines that run from the nose down to the corners of the mouth.

Restylane and Radiesse tackle aging signs like wrinkles and volume loss, but they shine in different ways. Restylane, a hyaluronic acid-based filler, is great for fine lines and adding volume to the face.

Injection Techniques and Treatment Process

Woman getting filler treatment.

Doctors use unique methods to put Restylane under the skin. They choose where and how deep to inject for the best look. These methods include linear threading, pulling a thin filler thread through the skin layer.

Another way is tunneling, making a path at the spot where skin and fat meet beneath the surface.

These techniques help fix lost volume and shape face parts nicely. The layering approach means putting Restylane at different depths for a better result. This careful process ensures natural-looking enhancement and rejuvenation of facial features.

Radiesse uses a unique approach to facial rejuvenation. The technique focuses on subcutaneous injections, carefully placing the filler beneath the skin to restore volume and stimulate collagen production.

This method fills in wrinkles and helps build a structural scaffolding that supports the skin’s natural elasticity. With Radiesse, medical professionals aim for precise areas needing volume enhancement or wrinkle reduction, tailoring each treatment to meet individual patient needs.

Longevity, Cost, and Patient Satisfaction

Results with Restylane can impress for up to 12 months and, in some cases, even reach 18 months. Its thick consistency plays a significant role in its lasting effects for dramatic enhancement.

Shifting our focus from Restylane, Radiesse stands out for its long-lasting effects. Thanks to its unique composition, this filler can keep wrinkles at bay for 12 to 18 months. It’s not just about filling in lines; Radiesse works by volumizing and stimulating collagen production.


Both Restylane and Radiesse offer unique advantages for facial rejuvenation, and the choice between the two should be based on the patient’s specific needs and goals. Understanding the differences in formulation, treatment areas, injection techniques, longevity, cost, and patient satisfaction is essential for medical professionals to make informed decisions when selecting the most suitable filler for their patients.

By considering these factors, medical experts can optimize treatment outcomes and ensure patient satisfaction when using Restylane or Radiesse for facial rejuvenation.


1. What’s the main difference between Restylane and Radiesse?

Restylane uses a substance like our body’s natural moisturizer, while Radiesse uses tiny calcium balls to do its magic.

2. How long do Restylane results last?

Restylane can keep you looking good for about 6 to 18 months.

3. And what about Radiesse, how long does it last?

Radiesse sticks around a bit longer, with results lasting up to a year or even two.

4. Can I use Restylane or Radiesse anywhere on my face?

Yes, both fillers work in different areas of your face, but your doctor will tell you which is best for each spot.

5. Is there any downtime after getting these fillers?

Nope, you can get back to most of your day right after the treatment; you just might have some minor swelling or bruising for a bit.


American Society of Plastic Surgeons. (2021, April 27). Injectable Dermal Fillers Don’t Just Fill – They Also Lift, New Study Suggests. https://www.plasticsurgery.org/news/press-releases/injectable-dermal-fillers-dont-just-fill-they-also-lift-new-study-suggests

Akinbiyi T, Othman S, Familusi O, Calvert C, Card EB, Percec I. Better Results in Facial Rejuvenation with Fillers. Plast Reconstr Surg Glob Open. 2020 Oct 15;8(10):e2763. doi: 10.1097/GOX.0000000000002763. PMID: 33173655; PMCID: PMC7647625.

Steven H. Dayan, Benjamin A. Bassichis, Facial Dermal Fillers: Selection of Appropriate Products and Techniques, Aesthetic Surgery Journal, Volume 28, Issue 3, May 2008, Pages 335–347, https://doi.org/10.1016/j.asj.2008.03.004r